Decoding mixed signals

IF 2.9 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

ACS Chemical Health & Safety Pub Date : 2017-02-15 DOI:10.1038/nchembio.2316

Thomas J Gardella

引用次数: 1

Abstract

A new mechanism of functional crosstalk between two distinct G-protein-coupled receptors (GPCRs)—the parathyroid hormone receptor (PTHR) and β2-adrenergic receptor (β2 Ar)—that occurs at the level of G protein βγ subunits and a specific adenylyl cyclase isoform is identified. This crosstalk augments cAMP signaling by the PTHR from endosomes, and thus promotes the actions of PTH ligands in bone target cells.

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G-蛋白偶联受体：解码混合信号。

两种不同的G蛋白偶联受体（GPCR）--甲状旁腺激素受体（PTHR）和β2-肾上腺素能受体（β2 Ar）--之间的功能性串扰新机制在G蛋白βγ亚基和特定腺苷酸环化酶异构体的水平上发生。这种串联增强了 PTHR 从内泌体发出的 cAMP 信号，从而促进了 PTH 配体在骨靶细胞中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Chemical Health & Safety PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.10

自引率

20.00%

发文量

期刊介绍： The Journal of Chemical Health and Safety focuses on news, information, and ideas relating to issues and advances in chemical health and safety. The Journal of Chemical Health and Safety covers up-to-the minute, in-depth views of safety issues ranging from OSHA and EPA regulations to the safe handling of hazardous waste, from the latest innovations in effective chemical hygiene practices to the courts'' most recent rulings on safety-related lawsuits. The Journal of Chemical Health and Safety presents real-world information that health, safety and environmental professionals and others responsible for the safety of their workplaces can put to use right away, identifying potential and developing safety concerns before they do real harm.