Expression of HOXC10 gene regulates the growth and invasion of prostate cancer cells

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2021-01-03 DOI:10.3329/BJP.V16I1.50244

Hong-jun Song, Xuxiao Ye, T. Liang, Dongliang Yan, Zuowei Li

引用次数: 0

Abstract

The present study was undertaken to decipher the role of HOXC10 gene in regulating the growth and metastasis of prostate cancer. The results revealed significant (p<0.05) up-regulation of HOXC10 gene in human prostate cancer tissues and cell lines. The silencing of HOXC10 transcript level significantly (p<0.05) inhibited the growth and colony formation of DU145 and 22Rv1 prostate cancer cells. The DAPI staining revealed that inhibition of DU145 and 22Rv1 prostate cancer cell viability was due to the induction of apoptosis. The transwell assay showed that HOXC10 significantly (p<0.05) inhibits the invasion of prostate cancer cells. The Western blotting revealed that HOXC10 gene exerts its effects via modulation of Ras/Raf/MEK/ERK signaling cascade. Collectively, the results point towards the therapeutic potential of HOXC10 in the treatment of prostate cancer.

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HOXC10基因表达对前列腺癌症细胞生长和侵袭的调控

本研究旨在阐明HOXC10基因在调节癌症生长和转移中的作用。结果表明，HOXC10基因在人前列腺癌症组织和细胞系中有显著的上调（p＜0.05）。HOXC10转录水平的沉默显著抑制了DU145和22Rv1前列腺癌症细胞的生长和集落形成（p＜0.05）。DAPI染色显示DU145和22Rv1前列腺癌症细胞活力的抑制是由于细胞凋亡的诱导。transwell检测显示，HOXC10显著抑制前列腺癌症细胞的侵袭（p＜0.05）。Western印迹显示HOXC10基因通过调节Ras/Raf/MEK/ERK信号级联发挥其作用。总之，结果表明HOXC10在治疗前列腺癌症方面具有治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.