Role of Polyphenols and Flavonoids as Anti-Cancer Drug Candidates: A Review

IF 0.7 Q4 PHARMACOLOGY & PHARMACY

Pharmacognosy Research Pub Date : 2023-02-22 DOI:10.5530/pres.15.2.022

Medha Mohan Hegde, K. Lakshman, Mrs. Medha, Mohan Hegde

引用次数: 1

Abstract

Natural drug-based chemotherapeutic have advanced at an unprecedented rate over the past decade. Owing to protective roles in vegetation, and exceptional antioxidant qualities, polyphenols and flavonoids have demonstrated promising clinical implications in malignancies amongst other plant metabolites. It is widely debated how dietary flavonoids and polyphenols can prevent cancer. Flavonoids are believed to execute a significant role in cancer prevention and treatment, as corroborated from experimental studies, epidemiological research, and human clinical trials. Carcinogen deactivation, antimutagenic, cell cycle arrest, apoptosis and differentiation, suppression of vasculature, oxidative stress, and reversion of multidrug resistance are among the many mechanisms of action that have been discovered. The present review outlines the classification of various polyphenols and flavonoids and their potential as anticancer therapeutic agents.

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多酚和黄酮类化合物作为抗癌候选药物的作用：综述

在过去的十年里，以天然药物为基础的化疗以前所未有的速度取得了进展。由于多酚和黄酮类化合物在植物中的保护作用和卓越的抗氧化性能，在其他植物代谢产物中，它们在恶性肿瘤中具有良好的临床意义。饮食中的黄酮类化合物和多酚类化合物如何预防癌症一直备受争议。实验研究、流行病学研究和人体临床试验证实，黄酮类化合物在癌症预防和治疗中发挥着重要作用。致癌物失活、抗突变、细胞周期停滞、细胞凋亡和分化、血管系统抑制、氧化应激和多药耐药性逆转是已经发现的许多作用机制之一。本文综述了各种多酚和黄酮类化合物的分类及其作为抗癌治疗剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacognosy Research PHARMACOLOGY & PHARMACY-

自引率

14.30%

发文量

期刊介绍： Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.