Histomorphometric changes in the ovaries of thymectomized guinea pigs

Q4 Medicine

Italian journal of anatomy and embryology Pub Date : 2022-09-21 DOI:10.36253/ijae-13680

Murali Punniakotti, V.Nithya, James Villanueva

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Abstract

Hypothalamic-pituitary-gonadal axis function is necessary for maintaining proper female reproductive cycle. This study aimed to evaluate the ovarian histomorphometric and histoarchitectural changes in neonatal, prepubertal and pubertal thymectomized female guinea pigs. A total of 30 female guinea pigs, sham-operated (n-5) and thymectomized (n-5) were studied in each group. The diameter and number of ovarian follicles among the thymectomized and sham operated female guinea pigs during estrus phase of estrous cycle was compared. Gonadal and accessory reproductive organs weights and microscopic features were studied in the sham operated guinea pigs and thymectomized. There were statistically significant changes in the number and diameter of follicles in the ovary in neonatal thymectomized female guinea pigs, but no significant changes were observed in prepubertal and pubertal female guinea pigs. Neonatal thymectomized female guinea pigs showed significant changes in their weight as well as changes in the microscopic features including reduced thickness of myometrium of uterus and less mucosal folding in the fallopian tube compared to the sham-operated group. But prepubertal and pubertal thymectomy did not affect the weight and microscopic features of gonads and accessory reproductive organs. Depending on the time of thymectomy, these results indicate morphological changes in the ovaries after thymectomy in females.

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去胸腺豚鼠卵巢的组织形态学变化

下丘脑-垂体-性腺轴功能是维持正常女性生殖周期所必需的。本研究旨在评估新生儿、青春期前和青春期胸腺切除雌性豚鼠的卵巢组织形态计量学和组织结构变化。每组共研究了30只雌性豚鼠，假手术（n-5）和胸腺切除（n-5。比较了胸腺切除和假手术雌性豚鼠在发情周期发情期的卵泡直径和数量。在假手术的豚鼠和胸腺切除的豚鼠中研究性腺和辅助生殖器官的重量和显微镜特征。在新生儿胸腺切除的雌性豚鼠中，卵巢中卵泡的数量和直径有统计学上的显著变化，但在青春期前和青春期雌性豚鼠中没有观察到显著变化。与假手术组相比，新生儿胸腺切除雌性豚鼠的体重和微观特征发生了显著变化，包括子宫肌层厚度减少和输卵管粘膜折叠减少。但青春期前和青春期胸腺切除术对性腺和生殖辅助器官的重量和显微特征没有影响。根据胸腺切除术的时间，这些结果表明女性胸腺切除术后卵巢的形态学变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Italian journal of anatomy and embryology Medicine-Embryology

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： The Italian Journal of Anatomy and Embryology, founded in 1901 by Giulio Chiarugi, Anatomist at Florence University, is a peer-reviewed journal sponsored by the Italian Society of Anatomy and Embryology. The journal publishes original papers, invited review articles, historical article, commentaries, obituitary, and book reviews. Its main focus is to understand anatomy through an analysis of structure, function, development and evolution. Priority will be given to studies of that clearly articulate their relevance to the anatomical community. Focal areas include: experimental studies, contributions based on molecular and cell biology and on the application of modern imaging techniques; comparative functional morphology; developmental biology; functional human anatomy; methodological innovations in anatomical research; significant advances in anatomical education. Studies that are essentially descriptive anatomy are appropriate only if they communicate clearly a broader functional or evolutionary significance. All papers should be submitted in English and must be original works that are unpublished and not under consideration by another journal. An international Editorial Board and reviewers from the anatomical disciplines guarantee a rapid review of your paper within two to three weeks after submission.