Development of 3D-Printed Magnetic Micro-Nanorobots for Targeted Therapeutics: the State of Art

IF 4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2023-09-08 DOI:10.1002/anbr.202300018

Ningning Hu, Lujia Ding, Yuyi Liu, Kemin Wang, Bing Zhang, Ruixue Yin, Wenju Zhou, Zhuming Bi, Wenjun Zhang

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Abstract

Micro-/nanorobots (mn-robots), inspired by the versatile mechanisms found in natural microorganisms, show great potential in enabling innovative bio-applications. The 3D-printed magnetic mn-robots are substantially advanced to swim in vivo and to carry and release therapeutic agents in a controlled manner. To understand the state of the art of such robots and identify their development trend, this article presents a comprehensive and systematic review of the recent works on development of magnetic robots and their applications in biomedical engineering, with a particular focus on targeted therapeutic delivery. The developments in materials, fabrications, actuations, and applications with design for magnetic mn-robots are reviewed, and it is aimed to discover the limitations of the existing works and to identify the knowledge gap, thereby deriving future research directions on developing magnetic mn-robots, especially for their applications in targeted therapeutic delivery.

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用于靶向治疗的3D打印磁性微纳机器人的开发：最新进展

受天然微生物中发现的多功能机制的启发，微/纳米机器人在实现创新生物应用方面显示出巨大潜力。3D打印的磁性锰机器人在体内游泳以及以可控的方式携带和释放治疗剂方面取得了长足的进步。为了了解这种机器人的技术现状并确定其发展趋势，本文对磁性机器人的发展及其在生物医学工程中的应用进行了全面、系统的综述，特别是靶向治疗递送。综述了磁性锰机器人在材料、制造、驱动和设计应用方面的发展，旨在发现现有工作的局限性，并找出知识差距，从而得出开发磁性锰机器人的未来研究方向，特别是其在靶向治疗中的应用。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.