Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

European Pharmaceutical Journal Pub Date : 2019-11-01 DOI:10.2478/afpuc-2019-0018

H. Sunaryo, S. Siska, E. Hanani, RS. Anindita, N. Yanti, Lisa

引用次数: 2

Abstract

Abstract Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and clinical settings.

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皮脂藤乙醇提取物的镇痛抗炎活性评价。

Cordia属的乔木和灌木广泛分布在包括印度尼西亚在内的温暖地区。本研究的目的是评估植物叶乙醇提取物对Wistar白化大鼠的镇痛和抗炎特性。采用热板法和醋酸致扭体法评价其镇痛活性，卡拉胶致爪水肿法测定其抗炎活性。结果表明，在测试的两种疼痛模型中，皮脂藤乙醇提取物（100、200和400 mg/kg）以剂量依赖的方式表现出显著的镇痛作用。该提取物在卡拉胶诱导的炎症试验中也表现出显著的抗炎作用。所获得的数据支持了传统民间传说中关于其镇痛和抗炎特性的治疗主张。尽管如此，还需要进一步的科学研究，以在其他实验模型和临床环境中确定其镇痛和抗炎特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.