CHITOSAN ADDUCT WITH TRANEXAMIC ACID AND ITS HAEMOSTATIC EFFECT

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2022-09-30 DOI:10.15259/pcacd.27.002

V. Antonyuk, Lidiia Panchak, R. Stoika, N. Manko, S. Khomyak

引用次数: 0

Abstract

Chitosan is a cationic polymer capable of binding acidic drugs. In addition, it has haemostatic and antimicrobial activity. Chitosan derivatives withanti-fibrinolytic properties may present increased effectiveness, especially when the added substance forms an adduct with chitosan. The aim of this work was to study the haemostatic action of the chitosan–tranexamic acid complex. Two chitosan solutions (molecularweight of 250 and 625 kDa at pH 5.7 and 6.2, and after tranexamic acid had been added to chitosan solutions) werestudied. Haemostatic evaluation was performed on white outbred mice. The time to complete cessation of bleeding from the tail was determined. Chitosan 625 kDa at pH 6.2 had the best haemostatic properties. Adding tranexamic acid to the chitosan solution reduced the bleeding time. This phenomenon was more pronounced for chitosan 625 kDa. Compared with control animals, this chitosan reduced bleeding arrest time by 30% and the chitosan–tranexamic acid adduct reduced the bleeding arrest time by 75%.

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壳聚糖与氨甲环酸的加合物及其止血作用

壳聚糖是一种能够与酸性药物结合的阳离子聚合物。此外，它还具有止血和抗菌活性。具有抗纤溶特性的壳聚糖衍生物可能表现出更高的效力，特别是当添加的物质与壳聚糖形成加合物时。本工作的目的是研究壳聚糖-氨甲环酸复合物的止血作用。研究了两种壳聚糖溶液（在pH 5.7和6.2下，以及在将氨甲环酸加入壳聚糖溶液后，分子量分别为250和625kDa）。对白色远红色小鼠进行止血评估。确定了完全停止尾部出血的时间。在pH6.2条件下，625kDa的壳聚糖具有最佳的止血性能。在壳聚糖溶液中加入氨甲环酸可缩短出血时间。对于625kDa的壳聚糖，这种现象更加明显。与对照动物相比，这种壳聚糖使止血时间减少了30%，壳聚糖-氨甲环酸加合物使止血时间缩短了75%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.