Potential of Mimosa pudica leaf in the treatment of ulcerative colitis in rat

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2018-08-14 DOI:10.3329/BJP.V13I3.35648

Bharati B Zaware, R. Gilhotra, S. Chaudhari

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引用次数: 4

Abstract

The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of Mimosa pudica. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with M. pudica ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of M. pudica leaf is effective in the treatment of ulcerative colitis.

Video Clip of Methodology:

Embedding or block making: 24 sec Full Screen Alternate

Tissue processing: 19 sec Full Screen Alternate

Section cutting: 33 sec Full Screen Alternate

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含羞草叶治疗大鼠溃疡性结肠炎的潜力

本研究的目的是验证其在治疗溃疡性结肠炎大鼠模型中的民间应用。将大鼠分为9组，每组6只。大鼠分别用氯仿、乙酸乙酯或含羞草乙醇提取物预处理7 d。为了诱导溃疡性结肠炎，大鼠直肠内注射2ml 4%醋酸溶液。对溃疡指数、结肠宏观观察、结肠组织和血液中髓过氧化物酶和丙二醛水平及结肠组织病理学进行了研究。直肠内滴注乙酸引起溃疡指数、结肠髓过氧化物酶和丙二醛升高。与标准药物强的松龙相比，褐皮霉乙醇提取物(400 mg/kg)预处理可显著降低溃疡指数、结肠髓过氧化物酶和丙二醛。本研究表明，苦参叶乙醇提取物对溃疡性结肠炎有较好的治疗作用。视频剪辑方法:嵌入或块制作:24秒全屏交替组织处理:19秒全屏交替切片切割:33秒全屏交替

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.