{"title":"Acyclic cucurbiturils and their applications","authors":"Hui Liu, You-Jia Guo","doi":"10.1007/s10847-022-01159-w","DOIUrl":null,"url":null,"abstract":"<div><p>Acyclic cucurbit[n]urils are a novel type of cucurbituril derivatives, consisting of a central glycoluril tetramer skeleton, two substituted terminal aromatic rings, and four linkers bearing solubilizing groups. Due to flexible conformation and facile functionalization, acyclic cucurbit[n]urils are tailored to exhibit high binding affinity and selectivity toward a variety of guests. In this review, we focus on the relationship between structure and property of acyclic cucurbit[n]urils. The recent development of acyclic cucurbit[n]urils has paved the way for practical applications in pharmaceutical and biochemical areas.</p></div>","PeriodicalId":638,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"102 9-10","pages":"723 - 733"},"PeriodicalIF":2.3000,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10847-022-01159-w","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 1
Abstract
Acyclic cucurbit[n]urils are a novel type of cucurbituril derivatives, consisting of a central glycoluril tetramer skeleton, two substituted terminal aromatic rings, and four linkers bearing solubilizing groups. Due to flexible conformation and facile functionalization, acyclic cucurbit[n]urils are tailored to exhibit high binding affinity and selectivity toward a variety of guests. In this review, we focus on the relationship between structure and property of acyclic cucurbit[n]urils. The recent development of acyclic cucurbit[n]urils has paved the way for practical applications in pharmaceutical and biochemical areas.
期刊介绍:
The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites.
The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.