Anxhela Akolli, S. Moretti, Francesca Mangiavacchi, Bonifacio Monti, C. Santi
{"title":"Mild and Green Protocol for Selective Deuteration of Quercetin-3-ORutinoside (Rutin) Under Aqueous Basic Conditions","authors":"Anxhela Akolli, S. Moretti, Francesca Mangiavacchi, Bonifacio Monti, C. Santi","doi":"10.2174/2213346106666190916105514","DOIUrl":null,"url":null,"abstract":"\n\nA convenient and cost-effective method for selective deuteration of rutin using biologically\ncompatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is\nbenign and inexpensive affording good results in very mild conditions allowing to reduce the required\namount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be\nconveniently followed by 1H-NMR.\n","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2213346106666190916105514","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Green Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213346106666190916105514","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 2
Abstract
A convenient and cost-effective method for selective deuteration of rutin using biologically
compatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is
benign and inexpensive affording good results in very mild conditions allowing to reduce the required
amount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be
conveniently followed by 1H-NMR.