Fluoride Plus Calcium Phosphate Varnishes: A Possible Link between Mineral Phase Formations and Observed Clinical Outcomes

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Hypotheses Pub Date : 2021-10-01 DOI:10.4103/denthyp.denthyp_117_21

R. Karlinsey

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引用次数: 1

Abstract

Introduction: Incorporation of calcium phosphate agents into fluoride varnishes might improve anticaries benefits. But when clinical results do not mirror this view, explanations remain unclear. The hypothesis: Our hypothesis is that better clinical outcomes are obtained from fluoride plus calcium phosphate varnishes when there is sustained, controlled release of mineralizing ions. Evaluation of the hypothesis: Calculations of ion activity products and putative mineral phases have been underutilized in assessing clinical outcomes of fluoride varnishes with calcium phosphate agents. In this study, a mineral phase comparison between a low-release varnish comprising functionalized tricalcium phosphate (fTCP) against a high-release varnish comprising casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) was made. These calculations revealed the predominance of hydroxyapatite, fluorapatite, and calcium fluoride formation for the varnish containing fTCP, whereas the varnish containing CPP-ACP produced the same minerals along with β-TCP and octacalcium phosphate. This hypothesis shows the mineral phases expected to form from fluoride plus calcium phosphate varnishes might bear on clinical outcomes.

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氟加磷酸钙清漆：矿物相形成与观察到的临床结果之间的可能联系

引言：在含氟清漆中加入磷酸钙制剂可能会提高防龋效果。但当临床结果不能反映这一观点时，解释仍然不清楚。假设：我们的假设是，当矿化离子持续、可控地释放时，氟化物加磷酸钙清漆可以获得更好的临床结果。假设的评估：离子活性产物和假定矿物相的计算在评估含磷酸钙试剂的氟清漆的临床结果时没有得到充分利用。在本研究中，对包含功能化磷酸三钙（fTCP）的低释放清漆与包含酪蛋白磷酸肽无定形磷酸钙（CPP-ACP）的高释放清漆之间的矿物相进行了比较。这些计算表明，对于含有fTCP的清漆，羟基磷灰石、氟磷灰石和氟化钙的形成占主导地位，而含有CPP-ACP的清漆产生了与β-TCP和磷酸八钙相同的矿物。这一假设表明，氟化物加磷酸钙清漆预计形成的矿物相可能会影响临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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