ACETYLCHOLINESTERASE, AS A POTENTIAL BIOMARKER OF NAPHTHALENE TOXICITY IN DIFFERENT TISSUES OF FRESHWATER TELEOST, ANABAS TESTUDINEUS

IF 1 4区环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES

Journal of Environmental Engineering and Landscape Management Pub Date : 2021-11-29 DOI:10.3846/jeelm.2021.15808

Susri Nayak, L. Patnaik

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引用次数: 2

Abstract

Naphthalene, a Polycyclic Aromatic Hydrocarbon is widely used as a fumigant and disinfectant despite its toxic effect and is ranked as the ninth most threatening compound. The present study was carried out to determine the in vivo effect of naphthalene at different concentrations on acetylcholinesterase (AChE) enzyme activity in different tissues of Anabas testudineus. The fishes were exposed to varying concentrations of naphthalene (4.2 mgL–1, 4.4 mgL–1, 4.6 mgL–1, 4.8 mgL–1 and 5 mgL–1) for a period of 72 hours. Acetylcholinesterase enzyme activity was found to be significantly inhibited, in a dose-response manner. The inhibition percentage of AChE activity varied from 9.34–43.95% in brain tissue, 2.56–35.81% in liver tissue, 5.94–34.15% in muscle tissue and 3.92–33.75% in gills in comparison to the tissues of the control group. Maximum inhibition of acetylcholinesterase enzyme activity in treated fish was observed in the brain followed by liver, muscles, and gills. This study highlights the significance and role of acetylcholinesterase as a potential stress biomarker of naphthalene toxicity.

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乙酰胆碱酯酶作为萘对淡水硬骨鱼不同组织毒性的潜在生物标志物

萘是一种多环芳烃，尽管具有毒性，但仍被广泛用作熏蒸剂和消毒剂，并被列为第九大威胁化合物。本研究旨在测定不同浓度的萘在体内对扁尾蛇不同组织乙酰胆碱酯酶（AChE）活性的影响。这些鱼暴露在不同浓度的萘（4.2 mgL–1、4.4 mgL–2、4.6 mgL–3、4.8 mgL–4和5 mgL–5）中72小时。乙酰胆碱酯酶活性被发现以剂量反应的方式被显著抑制。与对照组组织相比，脑组织中AChE活性的抑制率为9.34–43.95%，肝组织中为2.56–35.81%，肌肉组织中为5.94–34.15%，鳃中为3.92–33.75%。在处理过的鱼中，乙酰胆碱酯酶活性的抑制作用最大的是大脑，其次是肝脏、肌肉和鳃。这项研究强调了乙酰胆碱酯酶作为萘毒性的潜在应激生物标志物的意义和作用。

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来源期刊

Journal of Environmental Engineering and Landscape Management 环境科学-环境科学

CiteScore

1.90

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Environmental Engineering and Landscape Management publishes original research about the environment with emphasis on sustainability.