Comparative evaluation of clonidine and dexamethasone as adjuvants to ropivacaine for ultrasound-guided transversus abdominis plane block

IF 0.2 Q4 ANESTHESIOLOGY
Hemlata, R. Singh, R. Verma, D. Singh, A. Chaudhary, B. Kushwaha
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Abstract

Aim: This study aims to study the effect of addition of clonidine and dexamethasone to ropivacaine for ultrasound-guided TAP block in patients undergoing abdominal surgeries. We primarily compared the quality and duration of postoperative analgesia. Materials and Methods: This randomized double-blind study was done after taking approval from Institutional Ethical Committee and written informed consent from all the patients. Sixty patients undergoing abdominal surgery under general anesthesia were enrolled in the study and randomly divided into two groups: Group-RC (n = 30) and Group-RD (n = 30). Patients in both the groups were given bilateral ultrasound-guided TAP block at the end of surgery. Patients in Group-RC received 20 ml ropivacaine 0.2% with 75 μg clonidine on each side and patients in Group-RD received 20 ml ropivacaine 0.2% with 4 mg dexamethasone on each side. Results: Visual analogue scale score for pain was significantly less in Group-RC as compared to Group-RD at all-time intervals (P <.05). Duration of pain relief in Group-RC was significantly greater than in Group-RD (16.50 ± 6.68 vs. 9.67 ± 6.46 h; P = 0.001). Requirement of rescue analgesia was also significantly less in Group-RC as compared to Group-RD (80% vs. 90%; P = 0.014). Except for a higher incidence of nausea in Group-RC, there was no other significant difference in the incidence of complications between the two groups. Conclusion: Addition of Clonidine (75 μg) to ropivacaine for ultrasound-guided TAP block provides better and prolonged postoperative analgesia as compared to addition of dexamethasone (4 mg) without any significant side-effects.
可乐定和地塞米松辅助罗哌卡因用于超声引导下腹横肌平面阻滞的比较评价
目的:研究在罗哌卡因基础上加用可乐定、地塞米松进行超声引导下腹部手术患者TAP阻滞的效果。我们主要比较了术后镇痛的质量和持续时间。材料和方法:本随机双盲研究经机构伦理委员会批准并获得所有患者的书面知情同意后完成。60例全麻下腹部手术患者纳入研究,随机分为两组:rc组(n = 30)和rd组(n = 30)。两组患者均在手术结束时给予双侧超声引导下的TAP阻滞。rc组患者给予罗哌卡因0.2% 20 ml,每侧加75 μg可乐定;rd组患者给予罗哌卡因0.2% 20 ml,每侧加4 mg地塞米松。结果:与rd组相比,rc组疼痛视觉模拟评分在所有时间间隔内均显著降低(P < 0.05)。rc组疼痛缓解时间显著大于rd组(16.50±6.68∶9.67±6.46 h);P = 0.001)。与rd组相比,rc组对抢救性镇痛的需求也显著减少(80% vs 90%;P = 0.014)。除了rc组恶心发生率较高外,两组间并发症发生率无显著差异。结论:超声引导下TAP阻滞时,在罗哌卡因中添加可乐定(75 μg)比添加地塞米松(4 mg)具有更好、更持久的术后镇痛效果,且无明显副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Anaesthetists Forum
Indian Anaesthetists Forum ANESTHESIOLOGY-
自引率
0.00%
发文量
17
审稿时长
6 weeks
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