Recent advances in using liposomes for delivery of nucleic acid-based therapeutics

Q2 Pharmacology, Toxicology and Pharmaceutics

OpenNano Pub Date : 2023-05-01 DOI:10.1016/j.onano.2023.100132

Hamdi Nsairat , Walhan Alshaer , Fadwa Odeh , Ezzaldeen Esawi , Dima Khater , Abeer Al Bawab , Mohamed El-Tanani , Abdalla Awidi , Mohammad S. Mubarak

引用次数: 7

Abstract

Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class of therapeutics may change the field of disease treatment and personalized medicine since it can cure diseases. However, drug delivery systems are crucial for these therapeutics to fulfill their potential. Liposomes have long been considered ideal platforms for systemic drugs delivery. Considering the development in cancer therapeutics, this work emphases on the current advancements in liposomes’ Nano-formulations, functionalization, and design and how it has been applied to nucleic acid therapeutics. Accordingly, this review covers the literature that deals with liposomes in nucleic acid therapy.

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利用脂质体递送核酸治疗药物的最新进展

由于最近在生产和纯化方面的进步，核酸治疗正在迅速扩大。这类疗法可能会改变疾病治疗和个性化医疗领域，因为它可以治愈疾病。然而，药物输送系统对于这些疗法发挥其潜力至关重要。脂质体一直被认为是全身给药的理想平台。考虑到癌症治疗的发展，本工作重点介绍了脂质体纳米配方、功能化和设计的最新进展，以及它如何应用于核酸治疗。因此，本文综述了有关脂质体在核酸治疗中的应用的文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

OpenNano Medicine-Pharmacology (medical)

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

50 days

期刊介绍： OpenNano is an internationally peer-reviewed and open access journal publishing high-quality review articles and original research papers on the burgeoning area of nanopharmaceutics and nanosized delivery systems for drugs, genes, and imaging agents. The Journal publishes basic, translational and clinical research as well as methodological papers and aims to bring together chemists, biochemists, cell biologists, material scientists, pharmaceutical scientists, pharmacologists, clinicians and all others working in this exciting and challenging area.