Hypolipidemic Effect of Thymus munbyanus subsp. ciliatus Greuter & Burdet.: Guinea Pig as a Model for Tyloxapol-induced Hyperlipidemia

Pub Date : 2022-11-02 DOI:10.1080/22311866.2022.2162580

H. Elbouny, B. Ouahzizi, K. Sellam, C. Alem

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引用次数: 3

Abstract

Abstract Thymus munbyanus subsp. ciliatus Greuter & Burdet (T. munbyanus) is a thyme species with numerous traditional uses in Moroccan folk medicine. This thyme is rich in various bioactive compounds including polyphenols, and its intake would prevent several diseases, including hyperlipidemia and related disorders. This study aimed to evaluate the antioxidant activity using in-vitro tests and the hypolipidemic potential of the aqueous extract of this thyme using tyloxapol-induced hyperlipidemia in the guinea pig model. We found that T. munbyanus aqueous extract exhibited great hypolipidemic potential by lowering elevated levels of cholesterol (-50.64 %) and triglycerides (-80.36 %). Additionally, the extract of this thyme revealed significant amounts of total phenolic compounds (140.36 GAE mg/gE) including flavonoids (111.98 RE mg/gE), and exerts good antioxidant activity (DPPH IC50 = 0.43 mg/mL). We conclude that T. munbyanus aqueous extract is rich in antioxidant phytochemicals and its supplementation can be a useful natural treatment for the management of hyperlipidemia and cardiovascular disease. GRAPHICAL ABSTRACT

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胸腺的降血脂作用。纤毛虫格鲁特和伯德。:以豚鼠为模型的泰洛沙泊致高脂血症

摘要:胸腺亚种。ciliatus Greuter & Burdet (T. munbyanus)是一种百里香，在摩洛哥民间医学中有许多传统用途。百里香富含多种生物活性化合物，包括多酚，摄入百里香可以预防多种疾病，包括高脂血症和相关疾病。本研究旨在通过体外实验评价百里香水提物的抗氧化活性，并利用泰洛沙泊致高脂血症豚鼠模型评价百里香水提物的降血脂潜力。我们发现，紫竹水提物具有降低高胆固醇(- 50.64%)和甘油三酯(- 80.36%)的降血脂潜力。百里香提取物中总酚类化合物(140.36 GAE mg/gE)和总黄酮(111.98 RE mg/gE)含量显著，具有良好的抗氧化活性(DPPH IC50 = 0.43 mg/mL)。综上所述，水提物含有丰富的抗氧化植物化学物质，其补充可作为治疗高脂血症和心血管疾病的有效天然疗法。图形抽象

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