Structural study of anhydrous and hydrated 5-fluorouracil co-crystals with nicotinamide and isonicotinamide

IF 0.9 4区材料科学 Q3 CRYSTALLOGRAPHY

Zeitschrift Fur Kristallographie-Crystalline Materials Pub Date : 2021-12-28 DOI:10.1515/zkri-2021-2052

T. Heinen, Sandra Hoelscher, V. Vasylyeva

引用次数: 2

Abstract

Abstract 5-Fluorouracil is a widely used anti-cancer drug which exhibits diverse polymorphic and co-crystalline behavior. Here we report two new solvent-free co-crystals of 5-fluorouracil with model co-formers nicotinamide and isonicotinamide, along with the redetermination of their hydrated analogues. Selected co-formers are categorized as safe and therefore suitable for pharmaceutical applications. Differences and similarities in supramolecular topology of the given structures are discussed. A special emphasis is set on the influence of fluorine moieties on the overall packing and synthetic accessibility of the presented multi-component systems.

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无水和水合5-氟尿嘧啶与烟酰胺和异烟酰胺共晶体的结构研究

摘要5-氟尿嘧啶是一种应用广泛的抗癌药物，具有多种多态性和共结晶行为。在这里，我们报道了两种新的5-氟尿嘧啶与模型共形成物烟酰胺和异烟酰胺的无溶剂共晶体，以及它们的水合类似物的重新确定。选定的共形成剂被归类为安全的，因此适合于药物应用。讨论了给定结构的超分子拓扑结构的异同。特别强调氟部分对所提出的多组分系统的整体填充和合成可及性的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zeitschrift Fur Kristallographie-Crystalline Materials CRYSTALLOGRAPHY-

CiteScore

2.00

自引率

16.70%

发文量

期刊介绍： Zeitschrift für Kristallographie – Crystalline Materials was founded in 1877 by Paul von Groth and is today one of the world’s oldest scientific journals. It offers a place for researchers to present results of their theoretical experimental crystallographic studies. The journal presents significant results on structures and on properties of organic/inorganic substances with crystalline character, periodically ordered, modulated or quasicrystalline on static and dynamic phenomena applying the various methods of diffraction, spectroscopy and microscopy.