Synthesis, characterization, and biological activity of 1,3-disubstitued benzimidazolium salt and its Ag-NHC complex

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-04-28 DOI:10.20450/mjcce.2023.2589

Öznur Doğan Ulu

引用次数: 0

Abstract

In this study, a 1,3-dioxane functionalized benzimidazole salt and its Ag-complex were synthe-sized. The prepared compounds were structurally verified by several spectroscopic techniques including 1H NMR, 13C NMR, FT-IR, LC-MS, and C, H, N analysis. Compounds were evaluated for their in vitro antioxidant activity. The salts and their Ag-NHC complexes were further evaluated for their in vitro anti-cancer activities against HCT-116 human colon cancer cells. The results showed that complex 2 exhibited high activity (4.1 times) against the cancer cell lines studied when compared to the reference drug cispla-tin. Stability studies demonstrated that these compounds are stable in aqueous and organic solutions.

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1,3-二取代苯并咪唑盐及其Ag-NHC配合物的合成、表征和生物活性

本研究合成了1,3-二氧六环功能化的苯并咪唑盐及其ag配合物。通过1H NMR、13C NMR、FT-IR、LC-MS、C、H、N等光谱分析对化合物进行了结构验证。对化合物进行体外抗氧化活性评价。进一步评价了这些盐及其Ag-NHC复合物对HCT-116人结肠癌细胞的体外抗癌活性。结果表明，与参比药物顺铂相比，配合物2对肿瘤细胞系的活性高(4.1倍)。稳定性研究表明，这些化合物在水和有机溶液中都是稳定的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.