Analysis of correlation between NLR family pyrin domain containing 3 and nonalcoholic fatty liver disease

中国综合临床 Pub Date : 2019-05-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.03.004

K. Mu, L. Xue, W. Yao, Yanping Yang, Ying-jiu Zhai

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Abstract

Objective To explore the correlation between NLR family pyrin domain containing 3 (NLRP3) and nonalcoholic fatty liver disease (NALFD). Methods A cross-sectional study was conducted in this study.Eighty four cases of health examination personnel in Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital were included in the study randomly, and divided into NAFLD group(27cases) and normal control group(57cases) though liver ultrasound examination.Their general data (sex, height, weight), liver function, blood lipid, and blood glucose were analyzed.The level of NLRP3 in peripheral blood was analyzed by ELISA double antibody sandwich method.The relationship between NLRP3 and NAFLD was analyzed by Logistic regression. Results The prevalence of NAFLD was 32.1%(27/84). The levels of serum cholesterol, triglyceride, low density lipoprotein cholesterol, fasting blood sugar, alanine aminotransferase, creatinine and uric acid in NAFLD group were higher than those in normal control group (all P<0.01), while the level of serum high density lipoprotein cholesterol was lower than that in normal control group (P=0.023); the concentration of serum NLRP3 in NAFLD group was (5.1±1.8) μg/L, and that in normal control group was (3.9±1.4) μg/L.There was significant difference between the two groups (t=6.221, P=0.016). Logistic regression analysis showed that NLRP3 was a risk factor for NAFLD (OR=1.537, P=0.021). Conclusion The level of NLRP3 is up-regulated in the serum of NAFLD patients, which is related to the occurrence of NAFLD. Key words: NLR family pyrin domain containing 3; Nonalcoholic fatty liver disease; Inflammatory cytokine; Inflammasome

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NLR家族pyrin结构域3与非酒精性脂肪肝的相关性分析

目的探讨NLR家族pyrin结构域3（NLRP3）与非酒精性脂肪肝（NALFD）的相关性。方法采用横断面研究方法。随机选取上海医科大学附属周浦医院健康体检人员84例，经肝脏超声检查分为NAFLD组（27例）和正常对照组（57例）。分析他们的一般数据（性别、身高、体重）、肝功能、血脂和血糖。采用ELISA双抗体夹心法检测外周血NLRP3水平。采用Logistic回归分析NLRP3与NAFLD的关系。结果NAFLD患病率为32.1%（27/84），NAFLD组血清胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹血糖、丙氨酸氨基转移酶、肌酐和尿酸水平均高于正常对照组（均P<0.01），而血清高密度脂蛋白胆甾醇水平低于正常对照组，差异有统计学意义（P=0.023）；NAFLD组血清NLRP3浓度为（5.1±1.8）μg/L，正常对照组为（3.9±1.4）μg/L。两组差异有统计学意义（t=6.221，P=0.016）。Logistic回归分析表明，NLRP3是NAFLD的危险因素（OR=1.537，P=0.021），这与NAFLD的发生有关。关键词：NLR家族pyrin结构域包含3个；非酒精性脂肪肝；炎症细胞因子；易燃

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.