DETERMINATION OF CENTRAL NERVOUS EFFECT AND ANTIDOTAL EFFECT AGAINST CHLORPYRIFOS TOXICITY OF ALPHA-LIPOIC ACID THROUGH PHARMACOLOGICAL AND TOXICOLOGICAL CHALLENGES

Marwa Abdul-Ghani, A. Naser
{"title":"DETERMINATION OF CENTRAL NERVOUS EFFECT AND ANTIDOTAL EFFECT AGAINST CHLORPYRIFOS TOXICITY OF ALPHA-LIPOIC ACID THROUGH PHARMACOLOGICAL AND TOXICOLOGICAL CHALLENGES","authors":"Marwa Abdul-Ghani, A. Naser","doi":"10.21608/svu.2022.125628.1181","DOIUrl":null,"url":null,"abstract":"Toxicity Alpha-Lipoic Acid Abstract Pharmacological and toxicological challenges are among the most important studies in revealing the latent properties of drugs. The goal of this study was to evaluate the effects of alpha-lipoic acid on the central nervous system and chlorpyrifos toxicity in a chick’s model. One-day-old chicks were used, the pharmacological challenge was done through propofol anesthesia and calculate the onset, duration, and recovery time, and while chlorpyrifos was used in the toxicological challenge for the median lethal doses LD 50s were determined using the up-and-down method. Alpha-lipoic acid at 20, 40, and 80 mg/kg caused an inhibition effect on the central nervous system, represented by a significant increase in the anesthesia period when chicks were anesthetized by propofol at 20 mg/kg intraperitoneally. Alpha-lipoic acid caused a significant decrease in the recovery period compared to the control group. Alpha-lipoic acid at 20 and 40 mg/kg increased the value of the median lethal dose of chlorpyrifos by 31 and 62%, respectively. The use of alpha-lipoic acid as preanesthetic has benefits such as decreased recovery time, furthermore Alpha-lipoic acid has a depressant effect in the central nervous system. Alpha-lipoic acid revealed an antidotal effect against chlorpyrifos toxicity.","PeriodicalId":22190,"journal":{"name":"SVU-International Journal of Veterinary Sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"SVU-International Journal of Veterinary Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/svu.2022.125628.1181","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

Toxicity Alpha-Lipoic Acid Abstract Pharmacological and toxicological challenges are among the most important studies in revealing the latent properties of drugs. The goal of this study was to evaluate the effects of alpha-lipoic acid on the central nervous system and chlorpyrifos toxicity in a chick’s model. One-day-old chicks were used, the pharmacological challenge was done through propofol anesthesia and calculate the onset, duration, and recovery time, and while chlorpyrifos was used in the toxicological challenge for the median lethal doses LD 50s were determined using the up-and-down method. Alpha-lipoic acid at 20, 40, and 80 mg/kg caused an inhibition effect on the central nervous system, represented by a significant increase in the anesthesia period when chicks were anesthetized by propofol at 20 mg/kg intraperitoneally. Alpha-lipoic acid caused a significant decrease in the recovery period compared to the control group. Alpha-lipoic acid at 20 and 40 mg/kg increased the value of the median lethal dose of chlorpyrifos by 31 and 62%, respectively. The use of alpha-lipoic acid as preanesthetic has benefits such as decreased recovery time, furthermore Alpha-lipoic acid has a depressant effect in the central nervous system. Alpha-lipoic acid revealed an antidotal effect against chlorpyrifos toxicity.
通过药理学和毒理学挑战测定α-辛酸对毒死蜱毒性的中枢神经作用和解毒作用
毒性α-脂肪酸摘要药理学和毒理学挑战是揭示药物潜在特性的最重要研究之一。本研究的目的是在雏鸡模型中评估α-硫辛酸对中枢神经系统的影响和毒死蜱的毒性。使用一天大的雏鸡,通过丙泊酚麻醉进行药理学激发,并计算发作、持续时间和恢复时间,而在毒理学激发中使用毒死蜱时,使用上下法测定半数致死剂量LD50。20、40和80 mg/kg的α-硫辛酸对中枢神经系统产生抑制作用,表现为当小鸡被20 mg/kg的丙泊酚腹膜内麻醉时,麻醉期显著增加。与对照组相比,α-硫辛酸导致恢复期显著缩短。20和40 mg/kg的α-硫辛酸使毒死蜱的中位致死剂量值分别增加了31%和62%。使用α-硫辛酸作为前麻醉剂有减少恢复时间等好处,此外,α-硫油酸对中枢神经系统有抑制作用。α-硫辛酸具有抗毒死蜱毒性的解毒作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
25
审稿时长
16 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信