Encapsulation of hexanal in bio-based cyclodextrin metal organic framework for extended release

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2021-07-20 DOI:10.1007/s10847-021-01095-1

Ajay Kathuria, Trevor Harding, Rafael Auras, Mohsen B. Kivy

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引用次数: 9

Abstract

Porous materials have been widely studied for encapsulation and controlled release of active species for packaging applications. This study examines the encapsulation efficiency of hexanal in γ-cyclodextrin metal organic frameworks (γ-CDMOF) for potential active packaging applications. γ-CDMOF was synthesized and hexanal was encapsulated in the MOF using a vapor diffusion process. The synthesized MOF was characterized both before and after the encapsulation of hexanal using x-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). The diffraction peaks of various planes obtained from XRD characterization matched the theoretically calculated values. We identified the most stable docking sites using energy minimization calculations. FTIR and computational studied indicated hydrogen bonding interactions play a significant role in the stabilization of hexanal and γ-CDMOF inclusion complex. TGA characterization results revealed an encapsulation efficiency of about 15%. DSC and SEM study also supported encapsulation of hexanal in γ-CDMOF.

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己醛在生物基环糊精金属有机骨架中的包封缓释研究

多孔材料已被广泛研究用于包装应用的封装和活性物质的控释。本研究考察了己醛在γ-环糊精金属有机框架(γ-CDMOF)中的封装效率，为潜在的活性包装应用奠定了基础。合成了γ-CDMOF，并采用气相扩散法将己醛包封在MOF中。采用x射线衍射(XRD)、扫描电镜(SEM)、差示扫描量热法(DSC)、傅里叶红外光谱(FTIR)和热重分析(TGA)对己醛包封前后合成的MOF进行了表征。XRD表征得到的各平面衍射峰与理论计算值吻合。我们使用能量最小化计算确定了最稳定的对接地点。FTIR和计算研究表明，氢键相互作用对己醛和γ-CDMOF包合物的稳定起重要作用。TGA表征结果显示其包封效率约为15%。DSC和SEM研究也支持己醛包封在γ-CDMOF中。

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry Agricultural and Biological Sciences-Food Science

CiteScore

4.10

自引率

8.70%

发文量

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.