Eco-friendly and Green Procedure for Iodination of Reactive Aromatics Using PEG 400-I2/HIO3 Combination

IF 1.1 Q3 CHEMISTRY, MULTIDISCIPLINARY
A. K. Pathan, Pravinkumar Patil, A. Shinde, S. Zangade
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引用次数: 1

Abstract

Iodination of organic substrate is an important reaction for synthesis of pharmacological active molecules. In view of these concerns, we reported the convenient procedure for synthesis of iodo compounds using iodine and iodic acid in PEG-400.We have reported the eco-friendly procedure for preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400). The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines and heterocyclic compounds carried out using iodine, iodic acid and PEG-400. The synthesized substituted aromatic iodo compounds were confirmed based on spectral characterization and mixed melting points. The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative yields, and purity of iodo products.
PEG400-I2/HIO3组合用于活性芳烃碘化的环保绿色工艺
有机底物的碘化是合成药理活性分子的重要反应。考虑到这些问题,我们报道了在PEG-400中利用碘和碘酸合成碘化合物的简便方法。本文报道了以聚乙二醇(PEG-400)为绿色反应介质,以碘和碘酸为原料制备芳香族碘化合物的环保工艺。一些芳香族化合物如苯甲醛、苯乙酮、酚类、胺类和杂环类化合物的碘化使用碘、碘酸和PEG-400进行。通过光谱表征和混合熔点对所合成的取代芳香族碘化合物进行了验证。该方法具有反应步骤简单、分离容易、产率高、纯度高等优点。
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来源期刊
Current Green Chemistry
Current Green Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.30
自引率
13.60%
发文量
6
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