Eco-friendly and Green Procedure for Iodination of Reactive Aromatics Using PEG 400-I2/HIO3 Combination

Abstract

Iodination of organic substrate is an important reaction for synthesis of pharmacological active molecules. In view of these concerns, we reported the convenient procedure for synthesis of iodo compounds using iodine and iodic acid in PEG-400.We have reported the eco-friendly procedure for preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400). The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines and heterocyclic compounds carried out using iodine, iodic acid and PEG-400. The synthesized substituted aromatic iodo compounds were confirmed based on spectral characterization and mixed melting points. The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative yields, and purity of iodo products.