Methodology for the use of Equiverm-2.0% against equine parasite infections

Abstract

The purpose of the research is to develop a methodology for Equiverm-2.0% paste used against equine parasite infections.The methodology provides a brief description of Equiverm-2.0%, mechanism of its action, pharmaco-toxicological properties, application, slaughter terms, and personal safety measures. Equiverm-2.0% antiparasitic paste consists of the active ingredient, ivermectin, and excipients; it is a light cream-coloured paste with a slight pine odor and sweetish taste. The drug is administered orally at a therapeutic dose of 0.2 mg/kg for the active substance. One gram of paste is equal to 1 mL in volume with 20 mg of ivermectin. Ivermectin in Equiverm-2.0% paste is in a dissolved form, and forms an intermolecular complex. The antiparasitic paste is packaged in disposable polyethylene syringe dispensers of 5 or 10 mL, respectively, 4 to 8 g each, per treated horse weighing 400-800 kg. When administered orally, the paste spreads in the oral cavity and the animal eats it with pleasure due to its sweetish taste. The drug is recommended for registration in the Russian Federation.