Antidepressant effects of valproic acid in an animal model of depression

European Pharmaceutical Journal Pub Date : 2019-11-01 DOI:10.2478/afpuc-2019-0006

K. Buzgoova, L. Balagova, N. Hlavacova, D. Jezova

引用次数: 0

Abstract

Abstract Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of valproic acid has not been sufficiently characterized so far. The aim of the present study was to evaluate the antidepressant effect of valproic acid in an aldosterone model of depression. Subchronic treatment with valproic acid resulted in a reduction of the time spent in immobility in the forced swim test. In conclusion, the present study provides evidence on antidepressant effects of valproic acid using a classical behavioral approach for testing the efficacy of antidepressant drug in animal models.

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丙戊酸在抑郁症动物模型中的抗抑郁作用

摘要丙戊酸除了具有抗惊厥作用外，还被广泛用作双相情感障碍的情绪稳定剂。丙戊酸潜在的抗抑郁作用到目前为止还没有得到充分的表征。本研究的目的是评估丙戊酸在醛固酮抑郁症模型中的抗抑郁作用。丙戊酸亚慢性治疗可减少强迫游泳试验中静止不动的时间。总之，本研究使用经典的行为学方法在动物模型中测试抗抑郁药物的疗效，为丙戊酸的抗抑郁作用提供了证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.