Issue Information TOC

Abstract

Cover: In Prandi and Demichelis (https://doi.org/10.1002/cpbi.81), the image shows a cartoon of the computation of beta and allelic fraction of informative SNPs. (A) Example of the allelic fraction (AF) and beta (β) values computed for five genomic positions (p₁ to p_m) corresponding to five informative SNPs. Positions p₁ to p_n are within a hemizygously deleted genomic segment, A, whereas genomic positions p_{n + 1} to p_m lie within a wild-type genomic segment, B. (B to D) Examples of a normal cell and two different tumor cells. Tumor cells 1 and 2 differ in the status of genomic segment B. Histograms below the cell cartoons report the expected distribution of the AF of SNPs in genomic segments A and B together with the associated beta values. (E and F) Examples of two different tumor samples. Tumor sample 1 includes one normal cell and nine tumor cells with deleted genomic segment A and wild-type genomic segment B. Tumor sample 2 differs from tumor sample 1 in the presence of six tumor cells with a hemizygous deletion of genomic segment B. Expected distribution of the AF of informative SNPs together with estimated beta are depicted below each tumor sample cartoon.