Role of Her-2 in Gastrointestinal Tumours beyond Gastric Cancer: A Tool for Precision Medicine

IF 0.9 Q4 GASTROENTEROLOGY & HEPATOLOGY
C. Lengyel, B. Habeeb, S. Khan, K. El Bairi, S. C. Altuna, S. Hussain, S. Mazher, D. Trapani, A. Petrillo
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引用次数: 5

Abstract

Gastrointestinal (GI) tumors account for a quarter of all the cancer burden and a third of the global cancer-related mortality. Among them, some cancers retain a dismal prognosis; therefore, newer and innovative therapies are urgently needed in priority disease areas of high-unmet medical need. In this context, HER2 could be a relevant prognostic and predictive biomarker acting as a target for specific drugs. However, if the role of HER2 has been object of investigation for several years in gastric cancer, it is not well established in other GI malignancies. The aim of this narrative review was to portray the current landscape of the potential role of HER2 as a predictive biomarker for GI tumors beyond gastric cancer. In colon cancer, the benefit from anti-HER2 therapies is less clear than in gastric neoplasms for the lack of controlled studies. Pancreatic, biliary tract adenocarcinomas and hepatocarcinoma may derive a less clear clinical benefit by using anti-HER2 agents in HER2 positive tumors. Overall, the results are promising and seem to suggest that the integration of multiple modalities of therapies can optimize the cancer care. However, further prospective trials are needed to validate the use of personalized targeted therapies in this field.
Her-2在癌症后胃肠道肿瘤中的作用:精准医学工具
胃肠道肿瘤占癌症负担的四分之一,占全球癌症相关死亡率的三分之一。其中,一些癌症的预后不佳;因此,在医疗需求未得到高度满足的优先疾病领域,迫切需要更新和创新的疗法。在这种情况下,HER2可能是一种相关的预后和预测性生物标志物,作为特定药物的靶点。然而,如果HER2在癌症中的作用多年来一直是研究的对象,那么它在其他胃肠道恶性肿瘤中的作用还不明确。这篇叙述性综述的目的是描述HER2作为癌症以外胃肠道肿瘤的预测生物标志物的潜在作用的现状。在癌症中,由于缺乏对照研究,抗HER2疗法的益处不如胃肿瘤明确。通过在HER2阳性肿瘤中使用抗HER2药物,胰腺癌、胆道腺癌和肝癌可能获得不太明显的临床益处。总体而言,这些结果是有希望的,似乎表明多种治疗方式的整合可以优化癌症护理。然而,还需要进一步的前瞻性试验来验证个性化靶向疗法在该领域的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
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10 weeks
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