STUDY OF CHARACTERISTICS OF BEHAVIORAL REACTIONS OF RATS UNDER THE CONDITIONS OF EXPERIMENTAL STROKE WITH ANXIETY-DEPRESSIVE DISORDERS

Zh.H. Slobodyan, I. V. Savуtskyi
{"title":"STUDY OF CHARACTERISTICS OF BEHAVIORAL REACTIONS OF RATS UNDER THE CONDITIONS OF EXPERIMENTAL STROKE WITH ANXIETY-DEPRESSIVE DISORDERS","authors":"Zh.H. Slobodyan, I. V. Savуtskyi","doi":"10.32345/2664-4738.1.2023.05","DOIUrl":null,"url":null,"abstract":"Background. According to the estimates of the World Health Organization for 2021, 615 million people (about 10% of the population of the world) showed symptoms of depressive or anxious disorders. Among the main causes of death in the population, the first half of the year continues to suffer from diseases of the circulatory system, and forecasts indicate a savings trend to an increase. Therefore, the development of anxiety-depressive disorders on aphids of ischemic stroke is relevant. \nAim: to investigate the specificity of TDR on aphids of experimental ischemic stroke in the eyes. \nMaterials and methods. Experimental studies were carried out on 30 non-linear laboratory tests, which were divided into 3 groups: group 1 - contact control, group 2 - animals of the group with simulated ischemic stroke; 3rd group - blindness with modeled ischemic stroke and anxiety-depressive disorders. The recovery of ischemic stroke in juveniles was performed using an additional model of endovascular occlusion of the middle cerebral artery (focal ischemia) by E. Z. Longa. A model of reserpine-induced depression in the eyes was selected for the morbidized morbidity of pathophysiological lanquences of anxiety-depressive disorders. To assess the experimental behavioral models of depression on laboratory tests, we used tests - “open the field” and “apply a cross-like labyrinth”. \nResults. Achievements in the test \"chrest-like labyrinth\" were confirmed by an increase in the hour of turning the eyes in the dark sleeves of the labyrinth (a marker of increased anxiety) and a decrease in the hour of the change in the lighted cottages. Zokrema, in a group of animals with a modeled ischemic stroke, the latent period of entry to the dark chamber of growth (p<0.05), as well as in the eyes with comorbid pathology (p<0.05) was compared with the intact group. \nThere was a decrease in the hour of perebuvannya in clarified sleeves, as well as the number of clarified sleeves in both experimental groups of creatures. \nConclusion. Significant changes in psychophysiological tests were noted for the minds of an ischemic stroke, however, in animals with a modeled comorbid pathology, there were more manifestations of changes in all indications, which indicated a strengthening of the anxiety of that change. Obtained results require the destruction of pathophysiological mechanisms of depressive-anxious disorders on aphids of cerebrovascular changes.","PeriodicalId":52737,"journal":{"name":"Medichna nauka Ukrayini","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medichna nauka Ukrayini","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32345/2664-4738.1.2023.05","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background. According to the estimates of the World Health Organization for 2021, 615 million people (about 10% of the population of the world) showed symptoms of depressive or anxious disorders. Among the main causes of death in the population, the first half of the year continues to suffer from diseases of the circulatory system, and forecasts indicate a savings trend to an increase. Therefore, the development of anxiety-depressive disorders on aphids of ischemic stroke is relevant. Aim: to investigate the specificity of TDR on aphids of experimental ischemic stroke in the eyes. Materials and methods. Experimental studies were carried out on 30 non-linear laboratory tests, which were divided into 3 groups: group 1 - contact control, group 2 - animals of the group with simulated ischemic stroke; 3rd group - blindness with modeled ischemic stroke and anxiety-depressive disorders. The recovery of ischemic stroke in juveniles was performed using an additional model of endovascular occlusion of the middle cerebral artery (focal ischemia) by E. Z. Longa. A model of reserpine-induced depression in the eyes was selected for the morbidized morbidity of pathophysiological lanquences of anxiety-depressive disorders. To assess the experimental behavioral models of depression on laboratory tests, we used tests - “open the field” and “apply a cross-like labyrinth”. Results. Achievements in the test "chrest-like labyrinth" were confirmed by an increase in the hour of turning the eyes in the dark sleeves of the labyrinth (a marker of increased anxiety) and a decrease in the hour of the change in the lighted cottages. Zokrema, in a group of animals with a modeled ischemic stroke, the latent period of entry to the dark chamber of growth (p<0.05), as well as in the eyes with comorbid pathology (p<0.05) was compared with the intact group. There was a decrease in the hour of perebuvannya in clarified sleeves, as well as the number of clarified sleeves in both experimental groups of creatures. Conclusion. Significant changes in psychophysiological tests were noted for the minds of an ischemic stroke, however, in animals with a modeled comorbid pathology, there were more manifestations of changes in all indications, which indicated a strengthening of the anxiety of that change. Obtained results require the destruction of pathophysiological mechanisms of depressive-anxious disorders on aphids of cerebrovascular changes.
实验性脑卒中伴焦虑抑郁障碍大鼠行为反应特征研究
背景根据世界卫生组织2021年的估计,6.15亿人(约占世界人口的10%)出现抑郁或焦虑障碍症状。在人口死亡的主要原因中,今年上半年继续患有循环系统疾病,预测显示储蓄有增加的趋势。因此,对缺血性脑卒中蚜虫的焦虑抑郁障碍的发展是相关的。目的:探讨TDR对实验性眼部缺血性脑卒中蚜虫的特异性。材料和方法。对30项非线性实验室试验进行了实验研究,分为3组:第一组为接触对照组,第二组为模拟缺血性脑卒中组动物;第三组-失明伴缺血性中风和焦虑抑郁障碍。E.Z.Longa使用大脑中动脉血管内闭塞(局灶性缺血)的附加模型对青少年缺血性中风的恢复进行了研究。选择利血平诱导的眼睛抑郁模型来研究焦虑抑郁障碍的病理生理序列的发病率。为了在实验室测试中评估抑郁症的实验行为模型,我们使用了“开放领域”和“应用十字迷宫”测试。后果在“最像基督的迷宫”测试中,在迷宫的黑暗袖子中转动眼睛的时间增加了(这是焦虑增加的标志),而在明亮的小屋中改变眼睛的时间减少了,这证实了测试的成就。Zokrema,在一组模拟缺血性中风的动物中,与完整组相比,进入生长暗室的潜伏期(p<0.05)以及患有合并症的眼睛(p<0.05)。在澄清的袖子中,perebuvanya的小时数和澄清的袖子的数量都有所减少。结论缺血性中风患者的心理生理测试发生了显著变化,然而,在具有模拟共病病理的动物中,所有适应症都有更多的变化表现,这表明对这种变化的焦虑加剧。所获得的结果需要破坏抑郁焦虑障碍对蚜虫脑血管变化的病理生理机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
24
审稿时长
7 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信