Association between human Epstein–Barr virus and brain cancer: a systematic review and meta-analysis

IF 2.1 4区医学 Q3 VIROLOGY

Future Virology Pub Date : 2023-06-05 DOI:10.2217/fvl-2022-0219

S. Ghorbani, Vahid Tambrchi, Rana Farzi, A. Khatami, Rahil Nahid Samiei, H. Saadati, M. Noori, Arash Letafati, Atefeh Bahavar, Noorin Hezarpishe, Mehrshid Musavioun, Bahareh Mirzaei, Mohadeseh Sadat Meftagh, Najme Khodaei Doust, Fatemeh Hejami, S. J. Kiani

引用次数: 1

Abstract

Aim: The aim of this study was to investigate the pooled prevalence and potential correlation between Epstein–Barr virus (EBV) infection and brain cancers. Materials & methods: We searched for relevant studies in main databases and analyzed the heterogeneity, odds ratio and corresponding 95% CI among all studies using STATA software V.14. Results: Fourteen articles were included in the meta-analysis. The pooled prevalence of EBV among brain cancer patients was 9% (95% CI: 3–16%; I2 = 91.06%). An association was found between EBV and brain cancer (OR: 6.90 [95% CI: 1.81–26.28]; I2 = 0%]). Conclusion: The results of this study indicate a significant association between EBV infection and brain cancer, suggesting EBV infection is a potential risk factor for brain cancer development.

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人类爱泼斯坦-巴尔病毒与脑癌的关系:一项系统综述和荟萃分析

目的:本研究的目的是调查eb病毒(EBV)感染与脑癌的总患病率及其潜在相关性。材料与方法:我们在主要数据库中检索相关研究，使用STATA软件V.14分析所有研究的异质性、优势比和相应的95% CI。结果:14篇文章被纳入meta分析。脑癌患者中EBV的总患病率为9% (95% CI: 3-16%;i2 = 91.06%)。EBV与脑癌之间存在关联(OR: 6.90 [95% CI: 1.81-26.28];i2 = 0%])。结论:本研究结果提示EBV感染与脑癌有显著相关性，提示EBV感染是脑癌发展的潜在危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Virology 医学-病毒学

CiteScore

4.00

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.