Renal denervation in patients who do not respond to cardiac resynchronization therapy

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-05-19 DOI:10.1080/14017431.2022.2060526

Päivi Pietilä-Effati, Mathias Höglund, A. Käräjämäki, Filip Höglund, Anne-Maria Nabb, Eija Matila, M. Koistinen

引用次数: 1

Abstract

Abstract Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality in advanced heart failure (HF) in about two-thirds of the patients. Approximately one-third of the patients do not respond to CRT. The overactivity of sympathetic nervous system is associated with advanced HF and deteriorates the hemodynamic state. We tested the hypothesis that controlling sympathetic overactivity by renal denervation (RDN) could be beneficial in nonresponders for CRT. In our HeartF-RDN study (ClinalTrials.gov. NCT02638324), RDN could not reverse the progression of HF in subjects with New York Heart Association Classification (NYHA) III-IV stage symptoms.

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对心脏再同步治疗无反应患者的肾去神经支配

摘要心脏再同步治疗（CRT）可降低约三分之二的晚期心力衰竭（HF）患者的发病率和死亡率。大约三分之一的患者对CRT没有反应。交感神经系统的过度活动与晚期HF有关，并使血液动力学状态恶化。我们检验了通过去肾神经支配（RDN）控制交感神经过度活动可能对CRT无反应者有益的假设。在我们的HeartF RDN研究（ClinalTrials.gov.NCT02638324）中，RDN不能逆转纽约心脏协会分类（NYHA）III-IV期症状受试者的HF进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.