Progress in sepsis-associated encephalopathy therapy

Abstract

Sepsis-associated encephalopathy (SAE) is a common complication of sepsis.Not only the cognitive impairment which may develop in the future can reduce the quality of life, but also there is a high mortality in patients with this complication.There is no clear pathogenesis characterized and no specific therapy developed up to date.The synthetic treatment for sepsis is the most commonly used therapy.However, the treatment for encephalopathy is still under research.Therapy that can reduce inflammation caused by SAE, protect the blood-brain barrier, inhibit neurotransmitter abnormality, and restrain other key pathophysiology injuries should be developed in the future to prevent the permanent brain functional damage caused by SAE in patients. Key words: Sepsis; Encephalopathy; Treatment