Natural polysaccharides for ulcerative colitis: A general overview

IF 1.7 4区医学 Q3 TROPICAL MEDICINE

Asian Pacific journal of tropical biomedicine Pub Date : 2023-05-01 DOI:10.4103/2221-1691.377405

Nikhil Sharma, Akshita Arora, Dipti Kakkar

{"title":"Natural polysaccharides for ulcerative colitis: A general overview","authors":"Nikhil Sharma, Akshita Arora, Dipti Kakkar","doi":"10.4103/2221-1691.377405","DOIUrl":null,"url":null,"abstract":"Ulcerative colitis is a colonic disease characterized by the disruption of the mucosal epithelial layer and inflammation. For the treatment of this disease, various chemotherapeutic agents are available. However, the toxicities associated with chemotherapeutics greatly hamper treatment. Polysaccharide from natural resources is emerging as a potentially therapeutic substance with comparative minimum adverse effects. In this article, we are discussing polysaccharide from diverse sources (plants, edible mushrooms, and algae) which are being used in the treatment of ulcerative colitis. These polysaccharides exert their therapeutic action on ulcerative colitis through several mechanisms, including suppression of inflammatory cascades NF-ĸB, MAPK, IL-6/JAK2/STAT3, preventing the release of certain inflammatory mediators, modulating the intestinal microbiome, maintaining the integrity of intestinal barriers, and regulating the certain inflammatory markers. The present review compiles the role of different polysaccharides being used successfully in the management/treatment of ulcerative colitis. Special emphasis was given to explaining the biomolecular pathway.","PeriodicalId":8560,"journal":{"name":"Asian Pacific journal of tropical biomedicine","volume":"13 1","pages":"185 - 194"},"PeriodicalIF":1.7000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific journal of tropical biomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/2221-1691.377405","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"TROPICAL MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Ulcerative colitis is a colonic disease characterized by the disruption of the mucosal epithelial layer and inflammation. For the treatment of this disease, various chemotherapeutic agents are available. However, the toxicities associated with chemotherapeutics greatly hamper treatment. Polysaccharide from natural resources is emerging as a potentially therapeutic substance with comparative minimum adverse effects. In this article, we are discussing polysaccharide from diverse sources (plants, edible mushrooms, and algae) which are being used in the treatment of ulcerative colitis. These polysaccharides exert their therapeutic action on ulcerative colitis through several mechanisms, including suppression of inflammatory cascades NF-ĸB, MAPK, IL-6/JAK2/STAT3, preventing the release of certain inflammatory mediators, modulating the intestinal microbiome, maintaining the integrity of intestinal barriers, and regulating the certain inflammatory markers. The present review compiles the role of different polysaccharides being used successfully in the management/treatment of ulcerative colitis. Special emphasis was given to explaining the biomolecular pathway.

查看原文本刊更多论文

天然多糖治疗溃疡性结肠炎：综述

溃疡性结肠炎是一种以粘膜上皮层破坏和炎症为特征的结肠疾病。为了治疗这种疾病，可以使用各种化学治疗剂。然而，与化疗相关的毒性极大地阻碍了治疗。来自自然资源的多糖正在成为一种潜在的治疗物质，其不良反应相对最小。在这篇文章中，我们讨论了来自不同来源（植物、食用蘑菇和藻类）的多糖，这些多糖正在用于治疗溃疡性结肠炎。这些多糖通过多种机制对溃疡性结肠炎发挥治疗作用，包括抑制炎症级联反应NF-ĸB、MAPK、IL-6/JAK2/STAT3、防止某些炎症介质的释放、调节肠道微生物组、维持肠道屏障的完整性以及调节某些炎性标志物。本综述综述了不同多糖在溃疡性结肠炎管理/治疗中的成功应用。特别强调解释生物分子途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian Pacific journal of tropical biomedicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

3.10

自引率

11.80%

发文量

2056

审稿时长

4 weeks

期刊介绍： The journal will cover technical and clinical studies related to health, ethical and social issues in field of biology, bacteriology, biochemistry, biotechnology, cell biology, environmental biology, microbiology, medical microbiology, pharmacology, physiology, pathology, immunology, virology, toxicology, epidemiology, vaccinology, hematology, histopathology, cytology, genetics and tropical agriculture. Articles with clinical interest and implications will be given preference.