Anesthetic impact assessment of nefopam, xylazine, ketamine, propofol combination in local donkeys

Khaled M. Abdelbasset, A. A. Abdel-Hady, A. Soliman
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Abstract

Anesthesia is used in animals to relieve pain during surgical interference or other procedures which were likely causing pain. Safe, effective, and reversible anesthesia requires selecting proper anesthetic agents. This study aimed to evaluate the qualitative and quantitative aspects of total intravenous anesthesia (TIVA) induced by using nefopam/xylazine/ ketamine and propofol combination in local breed donkeys. Nefopam/xylazine/ ketamine and propofol anesthetic combination was evaluated for pain management by using nefopam to provide the maintenance of the anesthetic stage. The onset and duration of anesthetic induction, time of maintenance, and period of recovery were recorded. Furthermore, heart rate, respiratory rate, body temperature, and blood picture were analyzed before and after administration of the combination. Our findings revealed that administration of Nefopam/ xylazine/ ketamine and propofol combination led to a smooth induction with rapid onset within one minute. The anesthetic effect was maintained for approximately 31 minutes after continuous infusion of propofol for standard deviation (19±2 minutes). This was followed by a smooth recovery within approximately 48 minutes after induction of anesthesia. It concluded that nefopam/xylazine/ketamine and propofol infusion is considered satisfactory for pain management and provide satisfactory anesthesia for short surgical procedures in donkeys.
尼福泮、噻嗪、氯胺酮、异丙酚联用对驴麻醉效果的评价
麻醉用于动物在手术干扰或其他可能引起疼痛的过程中减轻疼痛。安全、有效、可逆的麻醉需要选择合适的麻醉剂。本研究旨在从定性和定量两方面评价尼福泮/噻嗪/氯胺酮和异丙酚复合麻醉对地方品种驴的全静脉麻醉效果。用尼福泮维持麻醉期,评价尼福泮/二嗪/氯胺酮和异丙酚联合麻醉对疼痛管理的影响。记录麻醉诱导的起效、持续时间、维持时间和恢复时间。并对两药联合用药前后的心率、呼吸频率、体温、血象进行分析。我们的研究结果显示,尼福泮/噻嗪/氯胺酮和异丙酚联合用药可在1分钟内平稳诱导并快速起效。持续输注异丙酚后,麻醉效果维持约31分钟,标准差(19±2分钟)。随后在麻醉诱导后约48分钟内顺利恢复。结论:尼福泮/噻嗪/氯胺酮和异丙酚输注对驴的疼痛管理是满意的,并为短时间手术提供满意的麻醉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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25
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16 weeks
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