Karakteristik Sediaan Hidroksiapatit dari Cangkang Kerang Simping (Amusium pleuronectes) dengan Perlakuan Suhu dan Waktu Sintesis

Abstract

Hydroxyapatite bioceramic (HAp) is a synthetic chemical component of calcium phosphate derivatives generally used to repair hard tissue damage. One of the natural ingredients for making hydroxyapatite is scallop shells (Amusium pleuronectes), a by-product of catching fresh scallops, which only use the adductor meat/muscle. This study aimed on HAp preparations from scallop shells and characterized the resulting hydroxyapatite formulation. The steps taken were preparing scallop shell flour, the calcination processed with temperatures of 700, 800, and 900 ° C and times 6; 4.5; and 3 hours, and the synthesis processed using Ammonium Dihydrogen Phosphate (ADP). The results obtained were the best hydroxyapatite treatment at a calcination temperature of 800 ° C for 4.5 hours with a yield of 75.20%. The functional group found of CO 3 2- indicated C-O vibrations from the CO 3 group and the hydrogen phosphate group (HPO 4 2- ). The diffractogram of HAp was similar to standard hydroxyapatite (HAp-S) with high intensity at values of 2θ: 25,88°; 31.75°; 32.18°; 32.88°; 34.05°; 39.77°; 46.61°; and 49.97°. HAp from this study has an agglomerate morphology, without sharp surface and edges. Based on SEM-EDS analysis, the HAp contains Ca and P 59.09 and 40.91%, respectively, with a Ca/P ratio of 1.44. The average particle diameter size was 396.88 nm. The morphology of the resulting HAp will be safe for human soft tissue application.