Epiretinal Membrane in Patients with Diabetic Macular Edema

IF 2.1 4区医学 Q2 OPHTHALMOLOGY

Ophthalmologica Pub Date : 2022-04-27 DOI:10.1159/000524742

Gilad Rabina, A. Hilely, D. Barequet, Shai Cohen, Naama Lipin, M. Mimouni, Adina R. Glick, A. Barak, A. Loewenstein, Shulamit Schwartz

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引用次数: 0

Abstract

Purpose: The aim of the study was to compare anatomical and functional outcomes of pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling in diabetes retinopathy patients with and without diabetic macular edema (DME). Methods: A retrospective interventional case series of consecutive patients who underwent PPV with ERM peeling. Patients were divided into two groups: those with and without preoperative DME. Visual acuity (VA) and optical coherence tomography parameters were evaluated before surgery and during 12 months of follow-up. Results: A total of 354 patients underwent PPV with ERM peeling, of which 51 met the inclusion criteria. Twenty-three were diagnosed with DME and were younger (66.3 ± 9.6 vs. 73.1 ± 8.2 years, p = 0.001), had longer diabetes mellitus (DM) duration (18.9 ± 7.1 vs. 14.3 ± 10.9 years, p = 0.04) and higher HbA1C% (7.6 ± 1.4 vs. 7.1 ± 1.3, p = 0.04). VA improved from 20/105 to 20/60 Snellen (p = 0.004) and central macular thickness decreased from 469.3 ± 64.9 μm to 331.1 ± 92.2 μm (p < 0.001) in the DME group and from 20/87 to 20/44 Snellen (p < 0.001) and from 463.1 ± 53.5 μm to 341.3 ± 49.5 μm (p = 0.01) in the non-DME group. Yearly intravitreal injection rate decreased from 5.9 ± 2.5 to 2.9 ± 3.0 (p < 0.001) injections in the DME group. Conclusions: DME patients with ERM experience significant improvement in VA, macular thickness, and yearly intravitreal injections after PPV with ERM peeling. DME patients are younger, with longer duration of DM and higher HbA1C% levels at presentation in comparison to diabetic ERM patients without DME.

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糖尿病性黄斑水肿患者的视网膜前膜

目的:本研究的目的是比较伴有和不伴有糖尿病性黄斑水肿(DME)的糖尿病视网膜病变患者行玻璃体切除(PPV)合并视网膜前膜剥离(ERM)的解剖和功能结果。方法:对连续接受PPV合并ERM脱皮的患者进行回顾性介入治疗。患者分为术前有DME组和无DME组。术前及随访12个月评估视力(VA)和光学相干断层扫描参数。结果:354例PPV合并ERM脱皮，其中51例符合纳入标准。23例诊断为DME，年龄较轻(66.3±9.6∶73.1±8.2岁，p = 0.001)，糖尿病病程较长(18.9±7.1∶14.3±10.9年，p = 0.04)， HbA1C%较高(7.6±1.4∶7.1±1.3,p = 0.04)。DME组VA由20/105 Snellen改善至20/60 Snellen (p = 0.004)，中央黄斑厚度由469.3±64.9 μm降至331.1±92.2 μm (p < 0.001)，非DME组由20/87 Snellen降至20/44 μm (p < 0.001)，由463.1±53.5 μm降至341.3±49.5 μm (p = 0.01)。DME组每年玻璃体内注射率由5.9±2.5降至2.9±3.0 (p < 0.001)。结论:DME合并ERM患者在PPV合并ERM剥落后VA、黄斑厚度和每年玻璃体内注射均有显著改善。与没有DME的糖尿病ERM患者相比，DME患者更年轻，DM持续时间更长，HbA1C%水平更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmologica 医学-眼科学

CiteScore

5.10

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.