Hubungan Antara Nilai Neutrophil-to-Lymphocyte Ratio (NLR) dengan Kadar Procalcitonin (PCT) pada Pasien COVID-19 di Kabupaten Jember

Jurnal Kesehatan Andalas Pub Date : 2022-12-26 DOI:10.25077/jka.v11i2.1999

Sofia Yusnur Rafida, Hairrudin Hairrudin, Muhammad Hasan

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Abstract

The neutrophil-to-lymphocyte ratio (NLR) and Procalcitonin (PCT) are biomarkers that represent inflammatory activity and immune status as predictors for the prognosis of COVID-19 patients. NLR values and PCT levels are positively correlated with the severity of COVID-19, but the relationship between the two biomarkers is unclear. Objectives: To analyzed the correlation between NLR values and PCT levels in COVID-19 patients in Jember Regency. Methods: This cross-sectional analytic observational study, conducted from March to April 2022, took data from 444 confirmed COVID-19 patients at the Jember Clinic Plantation Hospital. Secondary data were obtained from medical records of inpatients for the period January–December 2021. Results: The average NLR value was 8.58, while the average PCT level was 0.43 ng/mL. The results of the Spearman Correlation Analysis showed a positive correlation between NLR values and PCT levels in COVID-19 patients in the Jember Regency with a p-value = 0.00 and a moderate degree of correlation with an r count of 0.41. Conclusion: There is a positive correlation between NLR values and PCT levels for COVID-19 patients in Jember Regency. It is necessary to carry out routine NLR and PCT examinations to consider predictors of disease severity and prognosis in COVID-19 patients.Keywords: COVID-19, NLR, PCT

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Jember Cabouth新冠肺炎患者中性粒细胞-淋巴细胞比率（NLR）与降钙素原率（PCT）的关系

中性粒细胞与淋巴细胞比率（NLR）和降钙素原（PCT）是代表炎症活性和免疫状态的生物标志物，可作为新冠肺炎患者预后的预测因素。NLR值和PCT水平与新冠肺炎的严重程度呈正相关，但这两种生物标志物之间的关系尚不清楚。目的：分析Jember Regency新冠肺炎患者NLR值与PCT水平的相关性。方法：这项横断面分析观察性研究于2022年3月至4月进行，从詹伯诊所种植园医院的444名新冠肺炎确诊患者中获取数据。二级数据来自2021年1月至12月期间住院患者的医疗记录。结果：平均NLR值为8.58，而平均PCT水平为0.43 ng/mL。Spearman相关性分析结果显示，在Jember Regency的新冠肺炎患者中，NLR值与PCT水平呈正相关，p值=0.00，r计数为0.41，具有中等程度的相关性。结论：Jember Regency新冠肺炎患者的NLR值与PCT水平呈正相关。有必要进行常规NLR和PCT检查，以考虑新冠肺炎患者疾病严重程度和预后的预测因素。关键词：新冠肺炎，NLR，PCT

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Jurnal Kesehatan Andalas

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24 weeks