New Insights into Malaria Pathogenesis.

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2020-01-24 DOI:10.1146/annurev-pathmechdis-012419-032640

C. Moxon, M. Gibbins, D. McGuinness, D. Milner, M. Marti

引用次数: 82

Abstract

Malaria remains a major public health threat in tropical and subtropical regions across the world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 deaths per year, predominantly in young children in sub-Saharan Africa. Therefore, it is imperative to understand why a subset of infected individuals develop severe syndromes and some of them die and what differentiates these cases from the majority that recovers. Here, we discuss progress made during the past decade in our understanding of malaria pathogenesis, focusing on the major human parasite Plasmodium falciparum. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 15 is January 24, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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疟疾发病机制的新认识。

疟疾仍然是世界热带和亚热带地区的主要公共卫生威胁。尽管只有不到1%的疟疾感染是致命的，但这导致每年约43万人死亡，主要发生在撒哈拉以南非洲的幼儿中。因此，必须了解为什么一部分感染者会出现严重综合征，其中一些人会死亡，以及这些病例与大多数康复者的区别。在这里，我们讨论了过去十年来在理解疟疾发病机制方面取得的进展，重点是主要的人类寄生虫恶性疟原虫。《病理学年度评论：疾病机制》第15卷预计最终在线出版日期为2020年1月24日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.