A case of status epilepticus due to topical lidocaine toxicity: A case-report and review the literatures

Abstract

Introduction: Lidocaine hydrochloride is an acetamide derivative that was first introduced by Nils Löfgrene during 1943. It is a local anesthetic agent that is widely used in order to prepare patient for repairing lacerations in everyday practice. Neurological toxicities have been reported with systemic and topical lidocaine. Case Presentation: An 8-year-old female child was reported with a pure laceration who developed status epilepticus after receiving lidocaine along with ketamine. The patient had no medical history of epilepsy or allergic reaction and had a normal physical and mental development status. She received 200 mg lidocaine without epinephrine and underwent wound repair. The patient also received 60 mg of intramuscular ketamine in order to produce a relative sedation. After an hour of wound repair, she developed a tonic-colonic generalized seizure representative of status epilepticus seizure. The convulsions were managed by benzodiazepines, the patient was discharged without complication. Conclusion: Status epilepticus can happen due to lidocaine. Although patients usually recover with no major complications, obeying safety protocols can prevent these events.