Recent advances in diagnostics of neonatal hypoxic ischemic encephalopathy

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Bulletin of Russian State Medical University Pub Date : 2022-07-01 DOI:10.24075/brsmu.2022.038

N. Starodubtseva, ChM Eldarov, A. Kirtbaya, E. Balashova, A.S. Gryzunova, O.I. Ionov, VV Zubkov, DN Silachev

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引用次数: 1

Abstract

The prognosis in neonatal hypoxic ischemic encephalopathy (HIE) depends on early differential diagnosis for justified administration of emergency therapeutic hypothermia. The moment of therapy initiation directly affects the long-term neurological outcome: the earlier the commencement, the better the prognosis. This review analyzes recent advances in systems biology that facilitate early differential diagnosis of HIE as a pivotal complement to clinical indicators. We discuss the possibilities of clinical translation for proteomic, metabolomic and extracellular vesicle patterns characteristic of HIE and correlations with severity and prognosis. Identification and use of selective biomarkers of brain damage in neonates during the first hours of life is hindered by systemic effects of hypoxia. Chromatography– mass spectrometry blood tests allow analyzing hundreds and thousands of metabolites in a small biological sample to identify characteristic signatures of brain damage. Clinical use of advanced analytical techniques will facilitate the accurate and timely diagnosis of HIE for enhanced management.

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新生儿缺氧缺血性脑病诊断的最新进展

新生儿缺氧缺血性脑病（HIE）的预后取决于早期鉴别诊断和合理的紧急治疗性低温治疗。治疗开始的时刻直接影响长期的神经系统结果：开始得越早，预后越好。这篇综述分析了系统生物学的最新进展，这些进展有助于HIE的早期鉴别诊断，作为临床指标的关键补充。我们讨论了HIE的蛋白质组、代谢组和细胞外囊泡模式的临床翻译的可能性，以及与严重程度和预后的相关性。新生儿出生后最初几个小时大脑损伤的选择性生物标志物的识别和使用受到缺氧的全身影响的阻碍。色谱-质谱血液测试可以在一个小的生物样本中分析成百上千的代谢物，以确定脑损伤的特征特征。临床上使用先进的分析技术将有助于准确及时地诊断HIE，以加强管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.