Stem cell therapy of myocarditis and cardiomyopathies: a promising strategy

Abstract

The literature review is devoted to the analysis of modern data on the effectiveness of stem cell transplantation in patients with non-coronary heart diseases: myocarditis, dilated cardiomyopathy, and systemic amyloidosis with heart damage. The results of experimental studies on laboratory animals and clinical trials concerning the use of various types of stem cells, their mechanisms of action and prospects for application in non-coronary heart diseases are presented. Emphasis is placed on the need for further randomized multicenter clinical trials, especially in patients with inflammatory myocardial injury, involving a large number of patients.