Numerical Study of the Influence of the Geometric Parameters of a Radial Crystalizer Using a Multiscale CFD Model

Q4 Physics and Astronomy

Defect and Diffusion Forum Pub Date : 2023-07-14 DOI:10.4028/p-QO9GSb

Gustavo Villela Rodrigues, Cezar A. da Rosa

引用次数: 0

Abstract

This work investigates how the configuration of the geometric parameters of a radial crystallizer influences the results of the crystallization of lovastatin by antisolvent and using a multi-scale computational fluid dynamics (CFD) model. The OPENFOAM open-source software uses macro and micromixing expressions for flow, and complete energy and population equilibrium equations during nucleation and crystal growth. The model is based on the Reynolds-Averaged-Navier-Stokes (RANS) equation, along with a multi-environment probability density function (PDF) model and the spatially semi-discretized population equilibrium equation, operating a high-resolution finite volume method. The variation crystallizer construction parameters provided another crystallizer design, and analyses demonstrated improved performance and effects on crystal distribution.

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基于多尺度CFD模型的径向结晶器几何参数影响数值研究

本研究利用多尺度计算流体动力学(CFD)模型，研究了径向结晶器几何参数的配置对反溶剂作用下洛伐他汀结晶结果的影响。OPENFOAM开源软件使用宏观和微观混合表达式来表示流动，并完成成核和晶体生长过程中的能量和人口平衡方程。该模型基于reynolds - avered - navier - stokes (RANS)方程，以及多环境概率密度函数(PDF)模型和空间半离散人口平衡方程，采用高分辨率有限体积法。结晶器结构参数的变化提供了另一种结晶器设计，分析证明了结晶器性能的改善和对晶体分布的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Defect and Diffusion Forum Physics and Astronomy-Radiation

CiteScore

1.20

自引率

0.00%

发文量

127

期刊介绍： Defect and Diffusion Forum (formerly Part A of ''''Diffusion and Defect Data'''') is designed for publication of up-to-date scientific research and applied aspects in the area of formation and dissemination of defects in solid materials, including the phenomena of diffusion. In addition to the traditional topic of mass diffusion, the journal is open to papers from the area of heat transfer in solids, liquids and gases, materials and substances. All papers are peer-reviewed and edited. Members of Editorial Boards and Associate Editors are invited to submit papers for publication in “Defect and Diffusion Forum” . Authors retain the right to publish an extended and significantly updated version in another periodical.