The gut microbiome and potential implications for early-onset colorectal cancer

IF 2.7 Q3 ONCOLOGY

Colorectal Cancer Pub Date : 2020-09-01 DOI:10.2217/crc-2020-0007

Reetu Mukherji, B. Weinberg

引用次数: 8

Abstract

Recently, there has been an unexpected trend toward increased incidence of colorectal cancer in younger individuals, particularly distal colon and rectal cancer in those under age 50. There is evidence to suggest that the human gut microbiome may play a role in carcinogenesis. The microbiome is dynamic and varies with age, geography, ethnicity and diet. Certain bacteria such as Fusobacterium nucleatum have been implicated in the development of colorectal and other gastrointestinal cancers. Recent data suggest that bacteria can alter the inflammatory and immune environment, influencing carcinogenesis, lack of treatment response and prognosis. Studies to date focus on older patients. Because the microbiome varies with age, it could be a potential explanation for the rise in early-onset colorectal cancer.

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肠道微生物组及其对早发性癌症的潜在影响

最近，年轻人的结直肠癌癌症发病率出现了意外的上升趋势，尤其是50岁以下的结肠癌和癌症。有证据表明，人类肠道微生物组可能在致癌作用中发挥作用。微生物组是动态的，随年龄、地理、种族和饮食而变化。某些细菌，如核梭杆菌，与结直肠癌和其他胃肠道癌症的发展有关。最近的数据表明，细菌可以改变炎症和免疫环境，影响致癌、缺乏治疗反应和预后。迄今为止的研究主要集中在老年患者身上。由于微生物组随年龄的变化而变化，这可能是早发性癌症发病率上升的一个潜在解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Cancer ONCOLOGY-

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期刊介绍： Colorectal cancer is a major cause of morbidity and mortality, particularly in the developed world. Risk factors for colorectal cancer are on the rise in many countries; populations are aging, and obesity and diabetes are increasing. National screening programs are helping to detect cancer while it is still curable; however, colorectal cancer remains the third leading cause of cancer deaths in the USA and options are still limited for those with more advanced disease. Consequently, colorectal cancer is a major research priority for government, pharmaceutical companies and non-profit organizations. Research into diagnosis and optimum treatment of the disease is progressing rapidly, with new advances reported every day. Colorectal Cancer presents reviews, analysis and commentary. on all aspects of colorectal cancer.