Effects of ethylthiosulfanylate and chromium (VI) on the state of pro/antioxidant system in rat liver

Q4 Biochemistry, Genetics and Molecular Biology

Ukrainian Biochemical Journal Pub Date : 2020-11-13 DOI:10.15407/ubj92.05.078

B. Kotyk, R. Iskra, O. Slivinska, N. Liubas, A. Pylypets, V. Lubenets, V. I. Pryimych, U. Lviv

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引用次数: 6

Abstract

ethylthiosulfanylate is alkyl ester of thiosulfoacid and belongs to the class of thiosulfonate compounds. structurally, thiosulfonates are synthetic analogues of natural phytoncides. It is known that, natural organic sulfur-containing compounds are characterized by antioxidant and detoxification properties against heavy metals toxicity. therefore, the purpose of the study was to investigate the influence of ethylthiosulfanylate, as a synthetic analogue of natural phytoncides, on the state of the pro/antioxidant system in the liver of laboratory rats exposed to cr(vI). It was found that ethylthiosulfanylate exposure at a dose 100 mg/kg body weight daily for 14 days led to a decrease in the intensity of increasing of the lipid hydroperoxides (lhP) content in the rat liver caused by cr(vI) action. In addition, ethylthiosulfanylate pretreatment prevented depletion of reduced glutathione (Gsh) pool under the action of potassium dichromate oxidative stress and performed the accumulation of cellular Gsh in rat liver.

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亚磺酰亚乙基酯和铬（VI）对大鼠肝脏促/抗氧化系统状态的影响

乙基硫代氨基磺酸酯是硫代磺酸的烷基酯，属于硫代磺酸盐类化合物。在结构上，硫代磺酸盐是天然植物杀菌素的合成类似物。众所周知，天然有机含硫化合物具有抗氧化和解毒重金属毒性的特性。因此，本研究的目的是研究硫基亚磺酰乙酯作为一种天然植物杀菌剂的合成类似物对暴露于cr（vI）的实验室大鼠肝脏中促/抗氧化系统状态的影响。研究发现，以每天100mg/kg体重的剂量暴露于亚磺酰亚乙基酯14天导致由cr（vI）作用引起的大鼠肝脏中脂质氢过氧化物（lhP）含量增加的强度降低。此外，亚磺酰亚乙基酯预处理防止了在重铬酸钾氧化应激作用下还原型谷胱甘肽（Gsh）库的耗竭，并在大鼠肝脏中进行了细胞Gsh的积累。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ukrainian Biochemical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The Ukrainian Biochemical Journal publishes original research papers, reviews and brief notes; papers on research methods and techniques; articles on the history of biochemistry, its development and prominent figures; discussion articles; book reviews; chronicles; etc. The journal scope includes not only biochemistry but also related sciences, such as cellular and molecular biology, bioorganic chemistry, biophysics, pharmacology, genetics, and medicine (medical biochemistry et al.) – insofar as the studies use biochemical methods and discuss biochemical findings.