Immune response and cytokine storm in SARS-CoV-2 infection: Risk factors, ways of control and treatment

IF 0.6 4区医学 Q4 IMMUNOLOGY

European Journal of Inflammation Pub Date : 2022-01-01 DOI:10.1177/1721727X221098970

Hamid Chegni, H. Babaii, Z. Hassan, M. Pourshaban

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引用次数: 2

Abstract

In 2020, a deadly pandemic caused by the SARS-COV-2 virus spread worldwide and killed many people. In some viral infections, in addition to the pathogenic role of the virus, impaired immune function leads to inflammation and further damage in internal tissues. For example, coronavirus in some patients prevents the stimulation of the acquired immune system. Therefore, innate immunity is over-stimulated to compensate, followed by the overproduction of inflammatory cytokines and cytokine storm. Various underlying factors such as age, gender, blood pressure, diabetes, and obesity affect cytokine storm. It seems that cytokine storm is one of the leading causes of death among COVID-19 patients, and providing that this storm is detected and controlled in time, it can reduce the mortality of COVID-19 patients. This article aims to investigate the immune system response to COVID-19, various factors associated with cytokine storm, and its treatment. In the current situation, in parallel with the progress made in the field of vaccination, it is necessary to carefully examine the various dimensions of the immune system in response to the COVID-19 virus to seek a suitable treatment strategy to save the lives of patients in intensive care units

查看原文本刊更多论文

SARS-CoV-2感染的免疫反应和细胞因子风暴:危险因素、控制和治疗方法

2020年，由严重急性呼吸系统综合征冠状病毒2型引起的致命流行病在全球范围内传播，造成许多人死亡。在一些病毒感染中，除了病毒的致病作用外，免疫功能受损还会导致炎症和内部组织的进一步损伤。例如，一些患者的冠状病毒会阻止对获得性免疫系统的刺激。因此，先天免疫被过度刺激以进行补偿，随之而来的是炎性细胞因子和细胞因子风暴的过度产生。年龄、性别、血压、糖尿病和肥胖等多种潜在因素会影响细胞因子风暴。细胞因子风暴似乎是新冠肺炎患者死亡的主要原因之一，如果及时发现并控制这场风暴，它可以降低新冠肺炎患者的死亡率。本文旨在研究免疫系统对新冠肺炎的反应、与细胞因子风暴相关的各种因素及其治疗。在目前的情况下，在疫苗接种领域取得进展的同时，有必要仔细检查免疫系统应对新冠肺炎病毒的各个方面，以寻求合适的治疗策略来挽救重症监护室患者的生命

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Inflammation 医学-免疫学

CiteScore

0.90

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： European Journal of Inflammation is a multidisciplinary, peer-reviewed, open access journal covering a wide range of topics in inflammation, including immunology, pathology, pharmacology and related general experimental and clinical research.