Non-Coding RNAs and Wnt/β-Catenin Signaling Pathway in Gastric Cancer: From EMT to Drug Resistance

Onco Pub Date : 2021-11-25 DOI:10.3390/onco1020012

Bruno Takao Real Karia, Camila Albuquerque Pinto, C. Gigek, Fernanda Wisnieski, M. Arruda Cardoso Smith

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引用次数: 1

Abstract

Gastric cancer is one of the most common cancers and the third cause of cancer-related death worldwide. The treatment of GC patients improved due to advancements in surgery, radiotherapy and chemotherapy. However, the long-term survival rate of patients with gastric cancer remains around 20%. Thus, development of novel therapeutic approaches is of great interest, in order to reduce the need for mutilating surgeries and morbid adjuvant therapies. For many years, it was believed that the RNA was a mere intermediate molecule in the genetic information flow. However, during the past decades, with the advent of new sequencing technologies, it was revealed that non-coding RNAs play important roles in many different biological processes. The Wnt/β-catenin signaling pathway has been reported to regulate crucial events during neoplasic development, such as cell differentiation, proliferation, invasion, migration, apoptosis, and angiogenesis. In this review, we will focus on microRNAs and long non-coding RNAs that have been implicated in gastric cancer tumorigenesis via modulation of the Wnt/β-catenin signaling pathway, which provided some biomarkers to prognosis, diagnosis, and therapy.

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癌症非编码RNA与Wnt/β-儿茶酚胺信号通路：从EMT到耐药性

胃癌是最常见的癌症之一，也是全球癌症相关死亡的第三大原因。由于手术、放疗和化疗的进步，胃癌患者的治疗得到了改善。然而，胃癌患者的长期生存率仍保持在20%左右。因此，开发新的治疗方法是非常有趣的，以减少对肢解手术和病态辅助治疗的需要。多年来，人们一直认为RNA只是遗传信息流中的一个中间分子。然而，在过去的几十年里，随着新的测序技术的出现，人们发现非编码rna在许多不同的生物过程中发挥着重要作用。据报道，Wnt/β-catenin信号通路调节肿瘤发展过程中的关键事件，如细胞分化、增殖、侵袭、迁移、凋亡和血管生成。在这篇综述中，我们将重点关注通过调节Wnt/β-catenin信号通路参与胃癌肿瘤发生的microrna和长链非编码rna，这些rna为胃癌的预后、诊断和治疗提供了一些生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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