Clinical epidemiology and treatment outcome of Hexaconazole poisoning – A prospective six year study

A. Acharya, Abinash Panda
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引用次数: 2

Abstract

Background: Hexaconazole is a category 3/4 of poison as per the W.H.O Expert Group on Pesticide Residues. Hexaconazole is used to control infection by fungi in paddy and other crops. Apart from destroying the target species, it can also cause damage to humans. There have been discrete reports of instances of human poisoning due to hexaconazole. Methodology: A patient record-based cross-sectional study was carried out in Konaseema Institute of Medical Science & Research Foundation, Amalapuram, Andhra Pradesh, India during a period from March 2014 to April 2020 on 26 confirmed cases of hexaconazole poisoning. The clinic-demographic data, hematological, and biochemical parameters at the time of admission and at 72 hrs as well as the outcome were recorded and analyzed using descriptive statistics and paired t test. Result: The prevalence of hexaconazole poisoning was 4.79% of all poisoning cases. The major clinical presentation was gastrointestinal symptoms with vomiting being commonest. There was no significant change in the biochemical and hematological parameters. The mean duration of hospitalization was 4.93+1.39 days. The recovery rate was 100% without any major sequel. Conclusion: Poisoning due to hexaconazole is uncommon in comparison to poisoning by other pesticides in the agricultural community. The clinical manifestations of hexaconazole poisoning indicated that it is  of non-serious nature and its recovery was without any sequel.
六康唑中毒的临床流行病学及治疗效果——一项为期六年的前瞻性研究
背景:根据世卫组织农药残留专家组,六康唑是3/4类毒药。六康唑用于控制水稻和其他作物的真菌感染。除了摧毁目标物种外,它还会对人类造成伤害。曾经有过因六康唑而导致人体中毒的零星报告。方法:在2014年3月至2020年4月期间,在印度安得拉邦阿马拉普拉姆市科纳西马医学科学与研究基金会研究所对26例确诊的六氟康唑中毒病例进行了基于患者记录的横断面研究。记录两组患者入院时和72小时的临床人口学资料、血液学和生化指标及转归,采用描述性统计和配对t检验进行分析。结果:六硝唑中毒发生率为4.79%。主要临床表现为胃肠道症状,呕吐最为常见。生化、血液学指标无明显变化。平均住院时间为4.93+1.39天。回收率为100%,无重大后遗症。结论:与其他农药中毒相比,六康唑中毒在农业社区中较为少见。六康唑中毒的临床表现是非严重的,其恢复无后遗症。
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来源期刊
自引率
0.00%
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审稿时长
12 weeks
期刊介绍: Asia Pacific Journal of Medical Toxicology (APJMT) aims to expand the knowledge of medical toxicology and tries to provide reliable information in this field for medical and healthcare professionals. APJMT mainly focuses on research related to medical toxicology issues in the Asia Pacific region and publishes articles on clinical and epidemiological aspects of toxicology, poisonings emergency care, addiction, drug interactions and adverse effects. The journal accepts and welcomes high quality papers in the form of original articles and rarely review articles, case reports and scientific letters relevant to medical practice in toxicology.
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