FORMULATION AND CHARACTERISATION OF MUCOADHESIVE DENTAL APPLICATIONS CONTAINING BENZYDAMINE HYDROCHLORIDE

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2021-09-30 DOI:10.15259/pcacd.26.006

B. Grimling

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引用次数: 1

Abstract

The aim of this research was to develop a bioadhesive film based on benzydamine hydrochloride incorporated into natural bioadhesive polymers with different quantities of chitosan and guar gum but utilising a plasticiser. The obtained gels were deaerated by sonification, formed and evaporated by hot air drying; then, the properties were evaluated. Guar gum had a great influence on mechanical properties of the films – dynamic viscosity, texture, elasticity, stretching robustness, swelling and blur time. The formulations were used to obtain mucoadhesive films containing 0.3% benzydamine hydrochloride; they were tested for the release of the model drug. The amount of chitosan added to the formulation reduced the quantity of released substance and slowed down the release. Fouriertransform infrared spectroscopy did not reveal the creation of new chemical structures. In conclusion, the ratio of chitosan to guar gum in the medium impacts the mechanical properties and release parameters of the drug. These findings should enable researchers to match the parameter values to receive the most beneficial therapeutic outcome.

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含盐酸苄胺牙科黏合剂的配方及特性

本研究的目的是开发一种基于盐酸苄二胺的生物粘附膜，该膜与不同量的壳聚糖和瓜尔胶结合到天然生物粘附聚合物中，但使用增塑剂。通过超声处理对获得的凝胶进行脱气，通过热空气干燥形成并蒸发；然后对其性能进行了评价。瓜尔胶对薄膜的力学性能有很大影响——动态粘度、质地、弹性、拉伸稳定性、溶胀和模糊时间。所述制剂用于获得含有0.3%苯二胺盐酸盐的粘膜粘合剂膜；他们接受了模型药物的释放测试。添加到制剂中的壳聚糖的量减少了释放物质的量并减缓了释放。傅立叶变换红外光谱并没有揭示新化学结构的产生。总之，介质中壳聚糖与瓜尔胶的比例影响药物的力学性能和释放参数。这些发现应该使研究人员能够匹配参数值，以获得最有益的治疗结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.