Laboratory diagnostic value of neopterin measurements in patients with COVID-19 infection

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2021-01-01 DOI:10.1515/pteridines-2021-0001

D. Fuchs, M. Gisslén

引用次数: 5

Abstract

Abstract The new coronavirus SARS-CoV-2 was identified to be responsible for the COVID-19 pandemic. There are striking differences in the response to infection, some people develop no or mild symptoms, while other outcomes are severe of even fatal. For those COVID-19 patients who require hospitalization, prognostic markers could help clinicians to identify patients with a poor outcome early. The serum levels of the immune activation marker neopterin have already been shown to be of prognostic value in patients with SARS-CoV-1 and a similar pattern can be observed for SARS-CoV-2. This comment discusses the biochemical circuits that support the clinical value of neopterin measurements in COVID-19 patients.

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新蝶呤检测在COVID-19感染患者中的实验室诊断价值

摘要新型冠状病毒SARS-CoV-2被确定为新冠肺炎大流行的罪魁祸首。对感染的反应存在显著差异，一些人没有症状或症状轻微，而其他结果则严重甚至致命。对于那些需要住院治疗的新冠肺炎患者，预后标志物可以帮助临床医生早期识别结果不佳的患者。免疫激活标志物新蝶呤的血清水平已被证明对严重急性呼吸系统综合征冠状病毒1型患者具有预后价值，并且在严重急性呼吸系综合征冠状病毒2型患者中也可以观察到类似的模式。这篇评论讨论了支持新冠肺炎患者新蝶呤测量临床价值的生化回路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.