Hepatit B Virus DNA Flare During In Vitro Fertilization

Abstract

Potent antivirals are used for the treatment of hepatitis B infection. A 38-year-old female patient whose hepatit B virus (HBV) viral load was suppressed under tenofovir disoproxil fumarate treatment but had a viral flare during in vitro fertilization (IVF) treatment is presented. Although HBV DNA was negative continuously in the controls, an increase in HBV DNA was observed during IVF treatment. Hepatitis B has been isolated from many extrahepatic tissues. Ovarian stimulation is likely to increase viral replication. Therefore, it is essential to check HBV DNA periodically to prevent vertical transmission.