Citrus pectin based complexes for the tetracycline delivery

IF 4.6 Q1 CHEMISTRY, APPLIED
Y.V. Chekunkov, S.T. Minzanova, A.V. Khabibullina, D.M. Arkhipova, L.G. Mironova, A.D. Voloshina, A.R. Khamatgalimov, V.A. Milyukov
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Abstract

This research studied the formation of sodium polygalacturonate complexes with the antimicrobial drug "Tetracycline". The formation was confirmed by IR, UV and NMR spectroscopy. It was shown that the complexes were formed by electrostatic attraction and hydrogen bonding. The complexes demonstrated a high degree of drug binding to the polysaccharide matrix with the maximum content of tetracycline (6.68 wt %). The study of the antimicrobial activity of obtained compounds against S. aureus, B. cereus, E. coli showed no decrease in the antimicrobial effect compared to source tetracycline. Thus, the future research towards the new design compounds based on studied complexes could make contribution to a new generation of drugs based on pectin biopolymers.

Abstract Image

柑橘果胶为基础的四环素递送配合物
本研究研究了聚半乳糖酸钠与抗菌药物“四环素”的配合物的形成。通过红外光谱、紫外光谱和核磁共振光谱证实了该物质的形成。结果表明,配合物是由静电吸引和氢键作用形成的。该复合物与多糖基质结合程度高,四环素含量最高(6.68 wt %)。所得化合物对金黄色葡萄球菌、蜡样芽孢杆菌和大肠杆菌的抑菌活性研究表明,与四环素源相比,其抑菌效果没有下降。因此,未来基于所研究的配合物的新设计化合物的研究可以为新一代基于果胶生物聚合物的药物做出贡献。
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CiteScore
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