Is There a Relationship Between Cortisol and Treatment Response in Chronic Aphasia?

IF 1.8 4区医学 Q1 LINGUISTICS

Topics in Language Disorders Pub Date : 2022-07-01 DOI:10.1097/TLD.0000000000000291

Michelle Gravier, William D. Hula, Jeffrey P. Johnson, Alyssa M Autenreith, M. Dickey

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Abstract

Purpose: To evaluate whether levels of cortisol, a stress-related hormone, predicted response to intensive speech–language intervention for individuals with chronic aphasia (IWA). Secondary analyses explored baseline cortisol levels, change following intervention, association between cortisol levels and aphasia severity, self-reported communicative distress, and chronic stress. Method: Afternoon salivary cortisol levels were measured in 14 IWA during the first and last weeks of a 4-week intensive speech–language intervention epoch. Behavioral outcome measures were collected pre- and postintervention. Results: Cortisol levels did not significantly predict treatment response in this sample of IWA, although a positive trend was present. Baseline cortisol levels were not abnormally elevated, did not change from pre- to postintervention, and were not significantly correlated with any of the behavioral outcome measures. Discussion: Although afternoon salivary cortisol levels did not robustly predict treatment response in this participant sample, future studies may be warranted that include IWA with elevated levels of cortisol at pretreatment.

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慢性失语症患者皮质醇与治疗反应有关系吗?

目的:评估皮质醇(一种与压力相关的激素)水平是否能预测慢性失语症(IWA)患者对强化语言干预的反应。二级分析探讨了基线皮质醇水平、干预后的变化、皮质醇水平与失语严重程度、自我报告的沟通困难和慢性压力之间的关系。方法:在为期4周的强化语言干预阶段的第一周和最后一周，测量14名IWA的下午唾液皮质醇水平。在干预前和干预后收集行为结果测量。结果:皮质醇水平不能显著预测IWA患者的治疗反应，尽管存在积极的趋势。基线皮质醇水平没有异常升高，从干预前到干预后没有变化，并且与任何行为结果测量没有显着相关。讨论:尽管在该参与者样本中，下午唾液皮质醇水平并不能可靠地预测治疗反应，但未来的研究可能需要包括预处理时皮质醇水平升高的IWA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Language Disorders Multiple-

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Topics in Language Disorders (TLD) is a double-blind peer-reviewed topical journal that has dual purposes: (1) to serve as a scholarly resource for researchers and clinicians who share an interest in spoken and written language development and disorders across the lifespan, with a focus on interdisciplinary and international concerns; and (2) to provide relevant information to support theoretically sound, culturally sensitive, research-based clinical practices.