Overview of necroptosis and pyroptosis signaling pathways

Abstract

Cell death is an important event in the life cycle. Physical injury can cause cell death in eukaryotes. Besides, specific signaling pathway-mediated programmed cell death has attracted increasing attention. Currently, programmed cell death mainly includes apoptosis, programmed necrosis (necroptosis) and pyroptosis. Necroptosis and pyroptosis, as two new ways of programmed cell death, have been found to play a key role in the process of pathogen infection. Both necroptosis and pyroptosis have the characteristics of programmed lytic cell death, but the signaling pathways involved in them have significant differences. This review focused on the morphological characteristics, signal transduction pathways and the role played in the process of pathogen infection of necroptosis and pyroptosis. Key words: Necroptosis; Pyroptosis; Signaling pathway